No specific details are widely known about Anne's general health during her early childhood in Frankfurt and Amsterdam, other than typical childhood illnesses.

Living in the Secret Annex, Anne faced challenges maintaining good health due to limited food, fresh air, and medical care. The constant stress and anxiety also likely took a toll on her well-being. Minor illnesses and infections were probably common, but difficult to treat properly.

After being deported to Auschwitz and then transferred to Bergen-Belsen, Anne's health rapidly deteriorated due to starvation, overcrowding, poor sanitation, and exposure to harsh conditions. These camps had insufficient food, water, shelter, and medical attention.

Anne and Margot Frank succumb to typhus, a highly contagious disease spread by lice, in Bergen-Belsen. The exact date of their deaths is unknown, but it is believed to have been in February or early March 1945, just weeks before the camp was liberated.