Argegno (Comasco: Argegn) is a comune (municipality) in the Province of Como in the Italian region Lombardy, located about 50 kilometres (31 mi) north of Milan and about 15 kilometres (9 mi) north of Como. As of March 2024, it had a population of 679 and an area of 4.3 square kilometres (1.7 sq mi).

The local economy is heavily dependent upon tourism and the service industry. the official tourist website for Argegno is www.visitargegno.com.

A cable car can transport people up to the nearby village of Pigra.

Argegno is situated on an inlet in the lake, and is built alongside the River Telo which flows into the lake, the discharge of which is heavily dependent upon the season.

Argegno borders the following municipalities: Brienno, Colonno, Dizzasco, Lezzeno, Nesso, Pigra, Schignano. It is situated between the villages of Menaggio and Cernobbio.

Argegno is of Roman origin, and is named after the Roman consul Publio Cesio Archigene. With the fall of Rome and the subsequent geopolitical instability in Italy a series of fortifications were constructed in the medieval period, including the arched bridge which still stands. The largest structure in the village is the Sanctuary of Sant'Anna, which was constructed in the seventeenth century, and contains stucco work from later time.