Arlene Harris co-founded GreatCall, a telecommunications company focused on providing simple and affordable cell phones and services to seniors. This venture stemmed from her desire to address the unique communication needs of this demographic.

GreatCall developed and launched the Jitterbug phone, a simple and user-friendly mobile phone designed specifically for seniors. The Jitterbug phone became a popular choice among seniors due to its large buttons, simplified interface, and emergency assistance features.

Best Buy acquired GreatCall for $800 million. This acquisition validated GreatCall's success in serving the senior market and highlighted the growing demand for age-friendly telecommunication solutions. Arlene Harris continued to champion the cause of senior-focused technology.