Arylsulfatase L is an enzyme that, in humans, is encoded by the ARSL gene.

Arylsulfatase L is a member of the arylsulfatase subfamily of sulfatase enzymes that catalyze the hydrolysis of sulfate esters. It is glycosylated postranslationally and localized to the golgi apparatus. Sulfatases are essential for the correct composition of bone and cartilage matrix.

Deficiencies in ARSL are associated with X-linked recessive chondrodysplasia punctata, a disease characterized by abnormalities in cartilage and bone development.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.