The Baltimore City Health Department (BCHD) is the public health agency of the city of Baltimore, Maryland. BCHD convenes and collaborates with other city agencies, health care providers, community organizations and funders to "empower Baltimoreans with the knowledge, access, and environment that will enable healthy living."

The Baltimore City Health Department is organized into four divisions: Administration, Youth Wellness and Community Health, Population Health and Disease Prevention, and Aging and CARE (Commission on Aging and Retirement Education) Services. The Health Department has a wide-ranging area of responsibility, including acute communicable diseases, animal control, chronic disease prevention, emergency preparedness, HIV/STD, maternal and child health, restaurant inspections, school health, substance use, environmental health, health clinics, senior services, and youth violence issues.

The agency employs a workforce of approximately 1,100 employees and manages a budget of approximately $126 million. Dr. Letitia Dzirasa was named Baltimore City Health Commissioner in 2019.

Public health has always been a major issue in the city of Baltimore., with respect both to the business interests and the residents.

The Baltimore City Health Department was founded in 1793 and is the oldest continuously operating health department in the United States. It was established in response to the first recorded yellow fever outbreak in Baltimore at Fell's Point. On September 12, 1793, Governor Thomas Lee issued a proclamation appointing Baltimore's first health officers, Drs. John Worthington and John Ross .

Prior to 1793, Baltimore lacked a public health system but faced various health problems. For the majority of the 18th century, public health activity was centered on the reporting of “nuisances” and the government of Baltimore was managed by the town and special commissioners. In 1745, the town issued a prohibition against geese and swine running at large and in 1750, it enforced the removal of “stinking fish and dead creates or carrion” left out on streets. At the meetings of the Continental Congress in 1776 and 1777, delegates of the Continental Congress complained about the uncleanliness of Baltimore. Oliver Wolcott of Connecticut called Baltimore “the most dirty place I was ever in.” In November 1785, citizens of Baltimore petitioned Governor William Paca to establish a health office that could manage prevalent diseases and other health concerns. Their efforts were unsuccessful and the urgent need for a health department became apparent only after citywide outbreaks of yellow fever and smallpox later in the century.

The first health officers were called “quarantine physicians” and were tasked with the prevention of the spread of yellow fever further into Baltimore. During the same year, many French fleeing the Haitian Revolution were seeking refuge in Baltimore. Dr. John Ross was delegated the role of maritime quarantine and was responsible for stopping yellow fever from reaching beyond the port. Dr. John Worthington managed land quarantine and patrolled traffic on the roads between Baltimore and Philadelphia, a port city that was experiencing a massive yellow fever outbreak.

In 1794, a Committee of Health was established along with a quarantine hospital at Hawkins Point. On January 1, 1797, Baltimore officially became incorporated as a city and the public health department was placed in the control of nine health commissioners. The Board of Health (which in 1900 was named the “Department of Health”) was established as a branch of the city government and the Committee of Health came to be known as the “Commissioners of Health.”