The Basin and Range Province is a vast physiographic region covering much of the inland Western United States and northwestern Mexico. It is defined by unique basin and range topography, characterized by abrupt changes in elevation, alternating between narrow faulted mountain chains and flat arid valleys or basins. The physiography of the province is the result of tectonic extension that began around 17 million years ago in the early Miocene epoch.

The numerous ranges within the province in the United States are collectively referred to as the "Great Basin Ranges", although many are not actually in the Great Basin. Major ranges include the Ruby Mountains, the Snake Range, the Panamint Range, the White Mountains, the Toiyabe Range, the Sandia Mountains, and the Chiricahua Mountains. The highest point fully within the province is White Mountain Peak in California, while the lowest point is the Badwater Basin in Death Valley at −282 feet (−86 m). The province's climate is arid, with numerous ecoregions. Most North American deserts are located within it.

The Basin and Range Province should not be confused with the Great Basin, a region defined by its unique hydrological characteristics (internal drainage) that overlaps much of the greater Basin and Range physiographic region. Nor should it be confused with the Basin and Range National Monument, located in Southern Nevada, which is one small part of the much larger province.

The Basin and Range Province includes much of western North America. In the United States, it is bordered on the west by the eastern fault scarp of the Sierra Nevada and spans over 500 miles (800 km) to its eastern border marked by the Wasatch Fault, the Colorado Plateau and the Rio Grande Rift. The province extends north to the Columbia Plateau and south as far as the Trans-Mexican Volcanic Belt in Mexico, though the southern boundaries of the Basin and Range are debated. In Mexico, the Basin and Range Province is dominated by and largely synonymous with the Mexican Plateau.

Evidence suggests that the less-recognized southern portion of the province is bounded on the east by the Laramide Thrust Front of the Sierra Madre Oriental and on the west by the Gulf of California and Baja Peninsula with notably less faulting apparent in the Sierra Madre Occidental in the center of the southernmost Basin and Range Province.

Common geographic features include numerous endorheic basins, ephemeral lakes, plateaus, and bolson valleys alternating with mountains (as described below). The area is mostly arid and sparsely populated, although there are several major metropolitan areas, such as Reno, Las Vegas, Salt Lake City, Phoenix, Tucson, El Paso—Ciudad Juárez, Mexicali, and Hermosillo.

It is generally accepted that basin and range topography is the result of extension and thinning of the lithosphere, which is composed of crust and upper mantle. Extensional environments like the Basin and Range are characterized by listric normal faulting, or faults that level out with depth. Opposing normal faults link at depth producing a horst and graben geometry, where horst refers to the upthrown fault block and graben to the down dropped fault block.

The average crustal thickness of the Basin and Range Province is approximately 30–35 km and is comparable to extended continental crust around the world. The crust in conjunction with the upper mantle comprises the lithosphere. The base of the lithosphere beneath the Basin and Range is estimated to be about 60–70 km. Opinions vary regarding the total extension of the region; however, the median estimate is about 100% total lateral extension. Total lateral displacement in the Basin and Range varies from 60 to 300 km since the onset of extension in the Early Miocene with the southern portion of the province representing a greater degree of displacement than the north. Evidence exists to suggest that extension initially began in the southern Basin and Range and propagated north over time.