The Blue Ridge Parkway is a National Parkway and All-American Road in the United States, noted for its scenic beauty. The parkway, which is the longest linear park in the U.S., runs for 469 miles (755 km) through 29 counties in Virginia and North Carolina, linking Shenandoah National Park to Great Smoky Mountains National Park. It runs mostly along the spine of the Blue Ridge, a major mountain chain that is part of the Appalachian Mountains. Its southern terminus is at U.S. Route 441 (US 441) on the boundary between Great Smoky Mountains National Park and the Qualla Boundary of the Eastern Band of Cherokee Indians in North Carolina, from which it travels north to Shenandoah National Park in Virginia. The roadway continues through Shenandoah as Skyline Drive, a similar scenic road which is managed by a different National Park Service unit. Both Skyline Drive and the Virginia portion of the Blue Ridge Parkway are part of Virginia State Route 48 (SR 48), though this designation is not signed.

The parkway has been the most visited unit of the National Park System every year since 1946 except four (1949, 2013, 2016 and 2019). Land on either side of the road is owned and maintained by the National Park Service, and in many places parkway land is bordered by United States Forest Service property. There is no fee for using the parkway; however, commercial vehicles are prohibited without approval from the Park Service Headquarters, near Asheville, North Carolina. The roadway is not maintained in the winter, and sections that pass over especially high elevations and through tunnels are often impassable and therefore closed from late fall through early spring. Weather is extremely variable in the mountains, so conditions and closures often change rapidly. The speed limit is never higher than 45 mph (72 km/h) and is lower in some sections.

In addition to the road, the parkway has a folk art center located at mile marker 382 and a visitor center located at mile marker 384, both near Asheville. There are also numerous parking areas at trailheads for the various hiking trails that intersect the parkway, and several campgrounds located along the parkway allow for overnight stays. The Blue Ridge Music Center (also part of the park) is located in Galax, and Mount Mitchell (the highest point in eastern North America) is only accessible via North Carolina Highway 128 (NC 128), which intersects the parkway at milepost 355.4.

The parkway runs from the southern terminus of Shenandoah National Park's Skyline Drive in Virginia at Rockfish Gap to U.S. Route 441 (US 441) at Oconaluftee in the Great Smoky Mountains National Park near Cherokee, North Carolina. It is an undivided two-lane expressway for most of its route. Access is controlled via interchanges with local roads and state/US highways. The parkway crosses (but does not interchange with) several interstate highways along its route and is carried across streams, railway ravines and cross roads by 168 bridges and six viaducts. Frequent pull-offs, rest areas, and scenic overlooks line the sides of the road. Outside of the Asheville, Boone and Roanoke areas, it largely avoids major population centers, and the road parallels several US and Interstate Highways along sections of its route, which are generally used for longer haul traffic. Because of this, the road and its vistas are designed to be the attraction itself, rather than merely a means of efficient travel. The use of interchanges and grade separation at cross roads is designed to allow for freer flowing traffic and better vistas than frequent intersections and stoplights would allow for.

The parkway uses short side roads to connect to other highways, and there are no direct interchanges with Interstate Highways, making it possible to enjoy wildlife and other scenery without stopping for cross-traffic. Mileposts along the parkway start at zero at the northeast end in Virginia and count to 469 at the southern end in North Carolina. The mileposts can be found on the right-hand side of the road while traveling southbound on the parkway. Major towns and cities along the way include Waynesboro, Roanoke, and Galax in Virginia; and in North Carolina, Boone and Asheville, where it runs across the property of the Biltmore Estate. The Blue Ridge Parkway tunnels were constructed through the rock—one in Virginia and 25 in North Carolina.

Much of the parkway is located at high elevation, with colder, wetter and windier conditions than in surrounding areas. The highest point on the parkway (south of Waynesville, near Mount Pisgah in North Carolina) is 6,053 feet (1,845 m) above sea level on Richland Balsam at milepost 431. Sections of the parkway may be temporarily closed to repair damage caused by the cold winter climate of the mountains or for other maintenance. The parkway's natural resource protection protocol limits the use of ice melting chemicals, and certain areas could remain closed for extended periods. During road closures alternative routes are used, but short-term closures may not have a signed detour route. Sections of the parkway near the tunnels are often closed in winter due to icy conditions.

The Blue Ridge Parkway crosses the North Carolina–Virginia state line at mile 216.9. The 1749 party that surveyed the boundary included Peter Jefferson, father of Thomas Jefferson.

Begun during the administration of President Franklin D. Roosevelt, the project was originally called the Appalachian Scenic Highway.