Brest region, also known as Brest oblast or Brest voblasts, is one of the six regions of Belarus. Its administrative center is Brest. Other major cities in the region include Baranavichy, and Pinsk. As of 2024, it has a population of 1,308,569.

It is located in the southwestern part of Belarus, bordering the Podlasie and Lublin voivodeships of Poland on the west, the Volyn Oblast and Rivne Oblast of Ukraine on the south, the Grodno region and Minsk region on the north, and Gomel region on the east. The region covers a total area of 32,800 km², about 15.7% of the national total.

The westernmost point of Belarus is situated in Kamyenyets District near the town of Vysokaye.

2.7% of the territory is covered by Belovezhskaya Pushcha National Park, 9.8% is covered by 17 wildlife preserves of national importance.

It is often dubbed the Western gateway to Belarus. Geographically, the Brest region belongs to the area known as Polesia. The area of the region was part of the Second Polish Republic from 1921 until 1939 largely as the Polesie Voivodeship, when it was joined to the Byelorussian Soviet Socialist Republic. Northeastern part of it was administered as part of Nowogródek Voivodeship.

The Brest region has a population of 1,380,391, about 14,7% of the national total. About 47.2% of the region's population are men, and the remaining 52.8% are women. Number of inhabitants per 1 km2 is 43. Share of urban population is increasing continuously since the 1950s (17.1% in 1950, 70.5% in 2017).

Of the major nationalities living in the Brest region, 1,262,600 are Belarusians (85%), 128,700 (8.6%) are Russians, 57,100 (3.8%) are Ukrainians, and 27,100 (1.8%) are Poles. 53.7% of the population speak Belarusian and 42.6% speak Russian as their native language.

Brest is the province with the highest birth rate in all of Belarus. As of 2008, the birth rate was 12.0 per 1000 and death rate was 13.4 per 1000. In 2017, 12.4% of live births were to unmarried women (average in Belarus — 18.1%).