CCRL1

ACKR4
Identifiers
Aliases	ACKR4, CC-CKR-11, CCBP2, CCR-11, CCR10, CCR11, CCRL1, CCX CKR, CCX-CKR, CKR-11, PPR1, VSHK1, atypical chemokine receptor 4
External IDs	OMIM: 606065; MGI: 2181676; HomoloGene: 49474; GeneCards: ACKR4; OMA:ACKR4 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	132,618,967 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	104,004,132 bp
RNA expression pattern
	Top expressed in
	duodenum; ; ascending aorta; ; gallbladder; ; Descending thoracic aorta; ; subcutaneous adipose tissue; ; right coronary artery; ; skin of leg; ; Achilles tendon; ; skin of abdomen; ; pituitary gland;
	Top expressed in
	lip; ; morula; ; choroid plexus of fourth ventricle; ; body of femur; ; umbilical cord; ; esophagus; ; calvaria; ; thymus; ; stroma of bone marrow; ; zone of skin;
	More reference expression data
	n/a
Gene ontology
Molecular function	signal transducer activity; chemokine binding; scavenger receptor activity; G protein-coupled receptor activity; protein binding; chemokine receptor activity; C-C chemokine receptor activity; C-C chemokine binding;
Cellular component	recycling endosome; plasma membrane; membrane; endosome; integral component of membrane; early endosome; integral component of plasma membrane; external side of plasma membrane;
Biological process	receptor-mediated endocytosis; signal transduction; immune response; chemotaxis; G protein-coupled receptor signaling pathway; chemokine-mediated signaling pathway; positive regulation of cytosolic calcium ion concentration; calcium-mediated signaling; cell chemotaxis; vesicle-mediated transport; endocytosis;
	Sources:Amigo / QuickGO
Orthologs
	51554
	252837
	ENSG00000129048
	ENSMUSG00000079355
	Q9NPB9
	Q924I3
	NM_178445; NM_016557
	NM_145700
	NP_057641; NP_848540
	NP_663746
	Wikidata
View/Edit Human	View/Edit Mouse

C-C chemokine receptor type 11 is a protein that in humans is encoded by the CCRL1 gene.^[5]^[6]

The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. Alternatively spliced transcript variants encoding the same protein have been described.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000129048 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000079355 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Khoja H, Wang G, Ng CT, Tucker J, Brown T, Shyamala V (May 2000). "Cloning of CCRL1, an orphan seven transmembrane receptor related to chemokine receptors, expressed abundantly in the heart". Gene. 246 (1–2): 229–38. doi:10.1016/S0378-1119(00)00076-7. PMID 10767544.
^ ^a ^b "Entrez Gene: CCRL1 chemokine (C-C motif) receptor-like 1".

External links

Human ACKR4 genome location and ACKR4 gene details page in the UCSC Genome Browser.
Human CCR10 genome location and CCR10 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000129048 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000079355 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10767544-5] Khoja H, Wang G, Ng CT, Tucker J, Brown T, Shyamala V (May 2000). "Cloning of CCRL1, an orphan seven transmembrane receptor related to chemokine receptors, expressed abundantly in the heart". Gene. 246 (1–2): 229–38. doi:10.1016/S0378-1119(00)00076-7. PMID 10767544.

[entrez-6] "Entrez Gene: CCRL1 chemokine (C-C motif) receptor-like 1".

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CCRL1

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CCRL1

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