Cardcaptor Sakura (Japanese: カードキャプターさくら, Hepburn: Kādokyaputā Sakura), abbreviated as CCS, is a Japanese manga series written and illustrated by the manga group Clamp. Serialized monthly in the shōjo manga magazine Nakayoshi from the June 1996 to August 2000 issues, it was also published in 12 tankōbon volumes by Kodansha between November 1996 and July 2000. The story centers on Sakura Kinomoto, an elementary school student who discovers magical powers after accidentally freeing a set of magical cards into the world; she must retrieve the cards to prevent catastrophe. Each of these cards grants different magical powers, and can only be activated by someone with inherent magical abilities. A sequel by Clamp, Cardcaptor Sakura: Clear Card, focusing on Sakura in junior high school, was serialized in Nakayoshi from the July 2016 to January 2024 issues.

The manga was adapted into a 70-episode anime television series by Madhouse that aired on Japan's satellite television channel NHK BS2 from April 1998 to March 2000. Additional media include two anime films, video games, art books, picture books, and film comics. Tokyopop released the manga in English in North America from March 2000 to August 2003. After Tokyopop's license expired, Dark Horse Manga released the series in omnibus editions from October 2010 to September 2012. The anime was dubbed in English by Hong Kong's Omni Productions, and was aired in Southeast Asia and South Asia on the channel Animax Asia.

Nelvana licensed the TV series and first film for North America under the English title Cardcaptors, which first aired on Kids' WB from June 2000 to December 2001. All 70 episodes were dubbed; while other English-speaking territories received the full run, the version aired on American television was heavily edited into 39 episodes. Cardcaptors also aired on Cartoon Network (Toonami), Teletoon, Nickelodeon, Network Ten, and RTÉ2. The TV series and films were sub-licensed by Geneon, which released them unedited with English subtitles. The TV series was also released by Madman Entertainment in Australia and New Zealand.

Cardcaptor Sakura was critically well received. Critics praised the manga for its creativity and described it as a quintessential shōjo manga, as well as a critical work for manga in general. The manga series was awarded the Seiun Award for Best Manga in 2001. The television series was praised for transcending its target audience of young children and being enjoyable to older viewers, and for its artwork, humor, characterization, and animation; it won the Animage Grand Prix award for Best Anime in 1999. The American edit of Cardcaptors, however, was criticized for removing elements essential to the plot.

Cardcaptor Sakura takes place in the fictional town of Tomoeda, which is located somewhere near the Japanese capital of Tokyo. Ten-year-old Sakura Kinomoto accidentally releases a set of magical cards known as Clow Cards from a book in her basement created by and named after the sorcerer Clow Reed. Each card has its own unique ability and can assume an alternate form when activated. The guardian of the cards, Cerberus (nicknamed Kero), emerges from the book and explains that only a person with magical powers could open the seal of the book, revealing to Sakura that she can do magic. Kero chooses Sakura to retrieve the missing cards. As she finds each card, she battles its magical personification and defeats it by sealing it away. Cerberus acts as her guide, while her best friend and second cousin, Tomoyo Daidouji, films her exploits and provides her with both battle costumes and moral support. Sakura's older brother Toya Kinomoto watches over her, while pretending that he is unaware of what is going on.

Syaoran Li, a boy of Sakura's age and an indirect descendent of Clow Reed, arrives from Hong Kong to recapture the cards himself. While initially antagonistic, he comes to respect Sakura and begins aiding her in capturing the cards. Once Sakura captures all of the cards, she is tested by Yue, the cards' second guardian, to determine if she is worthy of becoming the cards' true master; Yue is also the true form of Yukito Tsukishiro, Toya's best friend whom Sakura has a crush on. Aided by her school teacher Kaho Mizuki, Sakura passes the test and becomes the new master of the Clow Cards.

Afterwards, Eriol Hiiragizawa, a transfer student from England and later confirmed as the reincarnation of Clow Reed (albeit one who holds only Clow Reed's memories and is not the sorcerer himself), arrives in Tomoeda and begins causing disturbances with two guardian-like creatures, Spinel Sun and Ruby Moon; the latter of whom takes on a human persona (Nakuru) and goes to the same school as Sakura's brother Toya. While under the guise of a female student Ruby Moon develops a strong crush on Toya while seeing Yukito as a love rival. At some point Yukito reveals to Sakura that he loves Toya, who later reveals indirectly to Yukito (while recovering after giving his magic to Yue to save both their lives) that he loves him in return. Sakura finds herself suddenly unable to use the Clow Cards and transforms her wand, beginning the process of evolving the cards into Sakura Cards as Eriol causes strange occurrences that forces her to use and thus transform certain cards. Once all the cards have been transformed, Eriol tells Sakura that he aided her in converting the cards so they would not lose their magic powers, while Spinel reveals to Sakura that Eriol stopped himself from ageing long ago so that he could go to class and befriend and help her. Syaoran later confesses his love to Sakura, who comes to realize she also loves him. Sakura reveals to Syaoran that she loves him back; telling him that he is her "Number One" (the person she loves the most). Syaoran reluctantly returns to Hong Kong but now knowing that Sakura loves him the same way he promises her that he will come back when he's finished with some business he needs to attend to there. He desperately asks Sakura if she will wait for him, and vows that she will. Over the next two years, Sakura and Syaoran maintain a long-distance relationship; making phone calls and writing letters to each other. On Sakura's first day of middle school, Syaoran moves back to Tomoeda permanently, and happily reunites with Sakura.

The plot of the anime series is extended, featuring 52 Clow Cards from the manga's original 19, and certain scenes are stretched and delayed, such as Cerberus' true form not being revealed until just before Yue's appearance. Sakura creates a 53rd card, Hope, a talent she is not shown to have in the manga. Some of the circumstances around the capturing of the cards is changed, such as Syaoran capturing several cards himself and being tested by Yue in the Final Judgment. Syaoran's cousin and fiancée Meiling Li is introduced in the anime, who positions herself as a jealous and romantic rival for Sakura and later becomes a friend until she returns to Hong Kong. The television series leaves the relationship between Sakura and Syaoran unresolved, but Sakura confesses her love to Syaoran at the end of the second anime film.