Chloroxylenol, also known as para-chloro-meta-xylenol (PCMX), is an organic compound with the formula (CH₃)₂ClC₆H₂OH. It is a chlorinated derivative of xylenol. The compound is a colorless solid, although impure samples can appear off-white. It has a phenolic odor. It is a common antiseptic.

Formulations containing chloroxylenol are used in hospitals and households as antiseptics, disinfectants, and sanitizers. It is commonly used in antibacterial soaps, wound-cleansing, and other household antiseptic applications. Chloroxylenol is used in various formulations and marketed under several brand names, including Dettol.

It is on the World Health Organization's List of Essential Medicines. When diluted, this chloroxylenol preparation is used as an antiseptic and disinfectant, and for skin disinfection. Diluted with alcohol, it is suitable for disinfecting medical instruments.

Chloroxylenol has been substituted for hexachlorophene and triclosan, which have been removed from world markets. It is currently used for control of bacteria, algae, and fungi in:

Chloroxylenol was first introduced to the United States in 1959. Chloroxylenol containing products must not be used in any manner that allows contamination of water.

The European Union allows chloroxylenol in cosmetics up to 0.5%.

Chloroxylenol is most effective against gram-positive bacteria. It works by disruption of the cell wall and stopping the function of enzymes. It is less effective than some other available agents. Testing has shown products containing chloroxylenol effective against the SARS-CoV-2 virus and orthopoxviruses. A meta-analysis found insufficient evidence to determine whether exposure creates bacterial resistance.

Chloroxylenol is produced by chlorination of the corresponding xylenol.