Christine of France (Christine Marie; 10 February 1606 – 27 December 1663) was Duchess of Savoy from 26 July 1630 to 7 October 1637 as the consort of Duke Victor Amadeus I. She was the daughter of Henry IV of France and sister of Louis XIII. Following her husband's death in 1637, she acted as regent of Savoy between 1637 and 1648.

Born in the Palais du Louvre in Paris, Christine was the third child and second daughter of King Henry IV of France and his second wife Marie de' Medici. As a daughter of the king, she was a Daughter of France. She was a younger sister of Louis XIII and Elisabeth of France and an older sister of Nicholas Henri, Duke of Orléans, Gaston, Duke of Orléans and Henrietta Maria of France. Christine was a sister-in-law of Philip IV of Spain through Elisabeth and of Charles I of England through Henrietta Maria. As a child, she was raised under the supervision of the royal governess Françoise de Montglat.

After the marriage of her older sister Elisabeth in 1615 to the future Philip IV of Spain, Christine took on the honorary title of Madame Royale, which indicated her status as the eldest and most senior unmarried daughter at the court of her brother. After her marriage, the style went to her younger sister Henrietta Maria.

Christine married Victor Amadeus I, Duke of Savoy, on 10 February 1619 at the Louvre in Paris. From 1619 till her husband's accession, she was known as the Princess of Piedmont. He was a son of Charles Emmanuel I, Duke of Savoy, and the Infanta Catherine Michelle of Spain. She was said to be volatile and frivolous. Educated at the French court, she introduced French culture to the court of Savoy. Her residences included the Palazzo Madama, which she had rebuilt, and she was also the driving force for the reconstruction of the Castello del Valentino as well as the additions to the Royal Palace of Turin. She would also later own Villa Abegg, the old residence of her brother-in-law Maurice of Savoy.

She did as much as she could to ensure that her court rivalled in splendour that of her sister Henrietta Maria, wife of Charles I of England. In spite of this, the two sisters maintained an avid correspondence throughout their life which showed their close relationship. She was a confidant to the exiled Queen Henrietta, who often wrote to her about her experiences during the English Civil War and her son's restoration. Christine encouraged her husband to claim his right to the rather empty title of King of Cyprus and Jerusalem, a 'kingdom' which led to him being tagged as 'a king without a crown'. She did not keep it a secret that she would rather have been a queen than a duchess, or that she also wanted to transform the minor Duchy of Savoy into a little France.

Victor Amadeus became Duke after the death of his father on 26 July 1630. When Christine's husband died in 1637, she was created regent in the name of her son Francis Hyacinth. At the death of Francis Hyacinth in 1638, her second son Charles Emmanuel II succeeded and Christine retained the regency.

Both Prince Maurice and his younger brother Prince Thomas of Savoy disputed the power of their sister-in-law and her French entourage. When the first heir Francis Hyacinth died in 1638, both brothers started the Piedmontese Civil War with Spanish support. The two parties were called "principisti" (supporters of the Princes) and "madamisti" (supporters of Madama Reale).

After four years of fighting, Christine was victorious, thanks to French military support. Not only did she keep the Duchy for her son, she also prevented France getting too much power in the Duchy. When peace was concluded in 1642, Maurice married his fourteen-year-old niece Louise Christine, abandoning the title of cardinal and asking dispensation from Pope Paul V. Maurice became governor of Nice. Christine of France stayed in firm control of the Duchy of Savoy until her son could follow in her footsteps; her formal regency ended in 1648, but she remained in charge at his invitation until her death.