Clan Home (pronounced and sometimes spelt Hume) is a Scottish clan. It held immense power for much of the Middle Ages and dominated the eastern Scottish Border country. It produced no fewer than eight Wardens of the Eastern March, more than any other family.

The Home family traces its male-line descent from Cospatric I (died after 1073), the Anglo-Celtic Earl of Northumbria. His descendant, William of Home (son of Sir Patrick of Greenlaw, the second son of Cospatric III, Earl of Lothian), adopted the surname following his acquisition of the lands of Home in Berwickshire in the early 13th century, through his marriage to his second cousin Ada (the daughter of Patrick I, Earl of Dunbar). William's arms featured the silver lion of Dunbar but with a green field instead of a red field, in reference to his lands of Greenlaw.

In the 14th century, William's descendant, Sir Thomas Home of that Ilk, married Nichola (also Nicola), heiress to the Pepdies of Dunglass. Through this marriage, the Homes acquired the lands of Dunglass, where they built Dunglass Collegiate Church (still extant today), and began quartering their arms with those of Pepdie, being three green papingoes 'parrots' in a silver field. This quartering is one of the earliest examples in Scottish heraldry.

Sir Thomas and Nichola had two sons. The first, Alexander, succeeded to the chieftaincy of the family, while the second, David, founded the family's principle cadet branch, the Homes of Wedderburn.

In 1402, Sir Alexander Home of that Ilk and of Dunglass was captured at the Battle of Homildon Hill. Later he followed the Earl of Douglas to France but was killed in the Battle of Verneuil in 1424. Most of the principal cadet branches of the clan are descended from his three sons. In 1473, his eldest grandson Sir Alexander was created a Lord of Parliament as Lord Home, and appointed a Warden of the Eastern March in c. 1475. In 1488, his grandson Alexander joined Prince James' rebellion against his father King James III, and had a commanding role in the Battle of Sauchieburn, which resulted in the death of the king. Following the battle, he was made a privy councillor and the Great Chamberlain. He succeeded his grandfather as 2nd Lord Home.

Alexander Home, 3rd Lord Home was appointed Lord Warden General in c. 1510. In 1513, he and his followers formed part of the army levied by King James IV to invade England. Lord Home led the vanguard of Scottish knights at the Battle of Flodden, and while he was fortunate enough to escape the slaughter, many of his family and supporters did not. Home was later appointed as one of the counsellors to the queen regent. However, the fortunes of the Homes suffered when the regency was transferred to the Duke of Albany. Lord Home was arrested for treason after being accused of conspiring with the English, and he and his brother were executed in October 1516. Their heads were then displayed on Edinburgh Tolbooth.

The title and estates were later restored to another brother, George Home, 4th Lord Home. On several occasions, he led Border spearmen against the English. However, he was thrown from his horse and died from his injuries on the eve of the Battle of Pinkie Cleugh in 1547. The Home lands were occupied by the English, but his son, Alexander Home, 5th Lord Home, retook them in 1549. He also supported the Scottish Reformation and sat in the Parliament of 1560 that passed the Protestant Confession of Faith.

During the politics of Mary, Queen of Scots, the Homes, like many others, shifted their allegiance more than once. Lord Home had supported the marriage of the Earl of Bothwell to Mary but he later led his men at the Battle of Langside against the queen. Then in 1573, he was arrested and convicted of treason against the young James VI of Scotland. He was released from Edinburgh Castle only after his health had failed, dying a few days later. His son, Alexander, the 6th Lord Home, a devoted supporter of James VI, served as ambassador to France multiple times.