Cotford St Luke (/ˈkɔːtfərd/) is a village and civil parish in Somerset, England. It is located approximately 2 miles (3.2 km) northwest of Norton Fitzwarren and 1.5 miles (2.4 km) south of Bishops Lydeard. The population recorded by the 2021 census is 2,642.

The village was established following the closure of Tone Vale Hospital and Cotford Asylum in the 1990s. The old asylum buildings were either demolished or converted into housing commencing in the late 1990s.

In 2011 the civil parish of Cotford St Luke was created; previously the village was part of Bishop's Lydeard civil parish – the new parish was formed entirely out of that parish. On 5 May 2011, Cotford St Luke Parish Council was first elected; seven parish councillors were elected un-opposed. In 2024, a series of resignations left the parish council without any members or a clerk.

The civil parish is 8.25 square kilometres (3.19 sq mi) in area.

The former hospital chapel – which was dedicated to Saint Luke – is a Grade II listed building built in the 1890s, and is located in the centre of the village. It has been converted into a public house/restaurant, called 'The Chapel', which opened on 13 July 2008 after being derelict for 18 years.

The village has a Southern Co-operative convenience store located near the centre, as well as a community centre/village hall which is situated next to the primary school in the south of the village, where there is also a village green and sports facilities.

Cotford St Luke Primary School is situated on the southern edge of the village. It was built on what were the grounds of the asylum playing fields and opened in September 2003. The school has 10 classes and caters for children from 4 to 11 years, with a pre-school on site for children from the age of 3 years.

The catchment area secondary school is Kingsmead School in Wiveliscombe. The school provides a free bus service for children in its catchment areas including Cotford St Luke.