The County of Gützkow (German: Grafschaft Gützkow) was a county located within the Duchy of Pomerania in the High Middle Ages. It was established in 1129 from the Castellany of Gützkow. Following the death of its last count in 1359, it was re-established into the Vogtei Gützkow.

Wartislaw was castellan of Gützkow until his death in 1219. His wife Dobroslawa, daughter of Bogislaw II, Duke of Pomerania, was styled Countess of Gützkow in a 1226 document approving the transfer of various lands to the nearby Stolpe Abbey. In 1234, Dobroslawa married the German noble Jaczo von Salzwedel, who expanded the old burgh on Gützkow's Schlossberg hill with stone buildings.

Around 1230, German settlers were invited to the sparsely settled central and northern areas devastated by earlier warfare. The German settlement was part of the pattern of larger migrations and social changes known as Ostsiedlung ("eastwards settlement"). Hanshagen was named after Count Johann I of Gützkow. Konrad II von Salzwedel, Jaczo's brother and since 1233 bishop of the Roman Catholic Diocese of Cammin (under the name Konrad III), advanced his relatives by enfeoffing them with lands belonging to Usedom Abbey (Grobe, Pudagla). Gützkow evolved into a town and was granted Lübeck law.

To oppose Eldena Abbey, which dominated the northern areas, Jaczo and Dobroslawa in 1242 founded a Franciscan friary (Grey Friars) in Greifswald, at this time the marketplace of Eldena. Hence this friary housed the tombs of the von Gützkow family. An inscription on the ceiling read:

The Counts of Gützkow also minted their own coins.

Jaczo's sons Johann I, Konrad and Jaczo II were until 1270 called Herren von Gützkow (lords of Gützkow), thereafter Grafen von Gützkow (Counts of Gützkow). The marriage of Jaczo II and Cecislawa of Putbus was already arranged by the time they were aged five and two, respectively, Cecislawa being a princess of a branch of the family of the princes of Rügen who ruled the areas north of Gützkow. Other arrangements connected the Gützkow family with the House of Pomerania. In 1295, Jaczo II was a witness to the internal partition of the Duchy of Pomerania, which made Gützkow a part of Pomerania-Wolgast. Jaczo's grandson, Nikolaus of Gützkow, was in 1319 appointed by Wartislaw IV of Pomerania-Wolgast to lead a court.

Johann III and Johann IV were involved in a conflict with the Pomeranian dukes about their mother Margarete's possessions. Margarete's brother, Bogislaw IV, Duke of Pomerania, had handed over the areas of Konsages, Schlatkow and Bünzow as dowry. Probably when Wartislaw IV, Duke of Pomerania, claimed these areas, they joined Pomerania's opponent Mecklenburg in the first war for the Rugian succession. After the Battle of Griebenow, the Counts of Gützkow settled the conflict, changed sides and fought for the dukes of Pomerania. In 1327 they besieged the town of Barth. In April 1328, an army led by the Counts of Gützkow and assisted by troops from Demmin and Altentreptow won the decisive Battle of Völschow against the troops of Heinrich II of Mecklenburg (the Lion).

In 1329 - 1334, Counts Johann III and Johann IV assisted the dukes of Pomerania-Stettin in the Pomeranian-Brandenburgian War against the Margraviate of Brandenburg. In 1331 (1334), they participated in the Battle of Kremmer Damm. Due to the high war costs, they sold many areas to the town of Greifswald, e.g. in 1334 - 1351 Sanz, Müssow and Guest.