Dante's Equation is a 2003 science fiction adventure novel by American writer Jane Jensen. It earned a Philip K. Dick Award Special Citation.

During the Holocaust, a genius Jewish scientist disappeared in a mysterious flash of light from a concentration camp. In 2005, unbeknownst to each other, a reporter in Los Angeles, an academic physicist in Seattle, a rabbi in Jerusalem, and a steel-hearted agent for the US Dept. of Defense are seeking his equations. They converge one night upon that same spot on the border of the concentration camp's grounds. All vanish through a micro black hole, each to reappear on a different world, where each will experience the bizarre reality of the physical rules of the multiverse.

The novel tells the story of the search for a law of physics, which theoretical physicists describe as a wave equation and rabbis as the attributes of Kabbalah. This principle delineates how the fifth dimension obeys a quasi-spiritual law of nature wherein Good and Evil control the lower dimensions. This insight was first discovered by Yosef Kobinski, who was interned in the Auschwitz concentration camp during World War II. Kobinski's manuscript, The Book of Torment, was written with any available materials; the pages were buried but, after the camps were liberated, recovered by a faithful follower. The equations describe a sort of Jacob's Ladder upon which souls are assigned to a new home according to their spiritual progress or regress. In the fifth dimension, data is organized like-to-like; and beings are attached to the physical location that most closely matches their souls.

A prefatory illustration, "Dante's Wheel," depicts how the characters' personalities are linked to the attributes of the divine Sefirot (as Jensen portrays them), which decide to which universes they are sent:

Denton Wyle, wealthy tabloid journalist for the Los Angeles-based Mysterious World, reports yarns of the Bermuda Triangle, ufology, and the supernatural, but is obsessed with mysterious disappearances because of a childhood incident: at 10, he actually saw a friend vanish in a flash of light. When he hears about Kobinski, he travels to upstate New York, Switzerland, and eventually Poland to collect fragments of The Book of Torment. Denton's research consists mostly of asking friends to explain science and history to him ("soaking up the atmosphere," since reading is too solitary), but he will stop at nothing to solve the mystery. In Jerusalem, Rabbi Aharon Handalman, a Talmudic scholar, discovers Kobinski's name in Torah code arrays and becomes determined to learn more, but accidentally passes his interest along to the Mossad. Violently patriotic Lieutenant Calder Farris professionally attends conferences on fringe theories, investigating anything that might lead to new weapons technology from non-recognized scientific sources.

University of Washington physicist Dr. Jill Talcott and her assistant Nate Andros independently rediscover Kobinski's wave equation and call it the One-Minus-One, to describe the wave peaks and troughs. They're onto an important scientific theory. Aharon's wife Hannah urges him to visit Yad Vashem and interview other Auschwitz survivors who knew Kobinski. He learns reluctantly from an eyewitness that Kobinski and his deadly enemy, a Nazi camp guard named Wallick, disappeared in a flash of light during a prison escape.

Jill and Nate set up an experiment with positive (One) and negative (Minus-One) radio wave pulses, which over the months demonstrate surprising results. As they increase the One pulses to 50%, 75%, and 90%, they discover that their fruit samples don't decay, that their lab mice procreate and their own sex drives grow, that a virus in a petri dish is inhibited, and that good luck increases dramatically. When they turn the pulse to the negative, however, their bad luck spreads correspondingly: they grow ill, students die in car accidents, their lab samples rot, and then their lab explodes. Jill winds up in the hospital with the flu, and Nate is followed by Calder's henchmen.

Aharon finds in the Torah codes, adjacent to 400 appearances of Kobinski's name, such phrases as "weapon of obliteration," "weapon loosing demons," and, eventually, dozens of incidences of "Jill Talcott." He flies to Seattle when he hears about the explosion. When Calder is told of it, he also flies to Seattle, to recruit Jill in order to take control of any military applications of the equation. She is about to accept his job offer when she is kidnapped from the hospital by Mossad agents; Nate rescues her, and they meet Aharon, who tells them what he has found in the Torah arrays. The three agree to fly to Poland together to visit camp survivor Anatoli Nikiel, who has the complete manuscript, and there they find Denton. Gun-toting Calder shows up that night in pursuit, and in yet another irruption of the One-Minus-One, all five enter Kobinski's black hole and vanish into different universes.