Dark Reign is a 2008 to 2009 comic book branding used by Marvel Comics. It deals with the aftermath of the "Secret Invasion" storyline, which resulted in a shift of power in the Marvel Universe toward Norman Osborn. The title refers to Osborn's rise to national power and the ramifications thereof. Joe Quesada, then-editor-in-chief of Marvel Comics, stated that "Dark Reign is not really an event, it's what's happening in the Marvel Universe." He believes that "Dark Reign leads to an interesting place in the Marvel Universe. I think you'll see a pulling back at the end of Dark Reign, but you'll understand at the end of it what we were trying to get to."

The story-line begins with the release of Secret Invasion: Dark Reign, a one-shot by Brian Michael Bendis (writer) and Alex Maleev (art), in December 2008. It continued in standalone mini-series and some individual issues of ongoing Marvel Comics titles throughout 2009. Selected ongoing Marvel titles were temporarily renamed to highlight their involvement in the story-line.

Initial promotional images for the story-line included a series of "We Lost, They Won" images showing: a severed robotic head of Iron Man, Emma Frost holding Cyclops's blood-covered visor, the new Captain America bowing to Norman Osborn's Iron Patriot form, Daken's Wolverine form looking down, Thor motionless on Loki's female form, Venom's Spider-Man appearance defeating Spider-Man, Hank Pym's Wasp alias (with Wasp's picture in the background), and the Green Goblin (which quotes that "He won").

There is no core limited series as there was in the preceding Secret Invasion event. Instead, the story-line is made up of one-shots that help fill in the gaps, limited series exploring the effect of the event on teams and individuals, as well as tie-ins with other ongoing series. The main story-line led into the 2010 "Siege" crossover event, although some plot elements are ongoing.

Following the Skrull invasion of Earth during Secret Invasion, Norman Osborn leverages his success in defeating the Skrulls to replace Tony Stark as director of S.H.I.E.L.D. Deadpool plays a large part in this, as he is supposed to send the information on how to kill the Skrull Queen Veranke to Nick Fury. An error occurs during the process and the information goes to Osborn instead. Osborn shoots Veranke in the head and becomes the director of S.H.I.E.L.D., which he replaces with H.A.M.M.E.R. Osborn simultaneously forms an alliance called the Cabal with Doctor Doom, Emma Frost, Namor, Loki, and the Hood. He uses H.A.M.M.E.R. to carry out his agenda and, at times, the Cabal's. However, Osborn's actions and his reputation influence a number of heroes and villains to attempt to resist Osborn's rule and remove him from power by force, if necessary.

"The Hood, of course, may not be acting of his own volition, since he has an unholy alliance with the Dread Dormammu, who may want the zombies and the virus that creates them for his own nefarious purposes. Plus, the Hood doesn't just bring any group of villains with him on this jaunt. He brings a very horror-oriented group of villains with him." (This group is the Night Shift.)

One-shots help the transition from Secret Invasion and fill in other details behind the main story-line.

Quasimodo enters the services of Norman Osborn as he puts together a dossier of different villains on which ones are a threat, should be locked up, or would be of use to Osborn. He compiles each villains according to threat, loyalty, influence, power, and expendability that are mentioned in their final assessment.