David William Sanborn (July 30, 1945 – May 12, 2024) was an American alto saxophonist. He worked in many musical genres; his solo recordings typically blended jazz with instrumental pop and R&B. He began playing the saxophone at the age of 11 and released his first solo album, Taking Off, in 1975. He was active as a session musician and played on numerous albums by artists including Stevie Wonder, Bruce Springsteen, Aretha Franklin, Sting, the Eagles, Rickie Lee Jones, James Brown, George Benson, Carly Simon, Elton John, Bryan Ferry, Ween, and The Rolling Stones. Sanborn released more than 20 albums and won six Grammy awards.

In 2012, Sanborn was described by critic Scott Yanow as "the most influential saxophonist on pop, R&B and crossover players of the past 20 years." He became identified with radio-friendly smooth jazz, although he disliked the term and said he was not a jazz musician.

Sanborn was born in 1945 in Tampa, Florida, where his father was stationed in the US Air Force. David grew up in Kirkwood, Missouri, a western suburb of St Louis. He contracted polio at the age of three. He "accepted his fate stoically" and endured a "miserable childhood". He was confined to an iron lung for a year, and polio left him with impaired respiration and a left arm shorter than the right.

While confined to bed, Sanborn was inspired by the "raw rock 'n' roll energy" of music he heard on the radio, particularly saxophone breaks in songs such as Fats Domino's "Ain't That a Shame" and Little Richard's "Tutti Frutti". He loved the sound of the saxophone and at the age of eleven was happy to change to saxophone from piano lessons when doctors recommended that he take up a wind instrument to improve his breathing and strengthen his chest muscles. When he was 14, he was competent enough playing saxophone to play with blues musicians in local clubs. Alto saxophonist Hank Crawford, who was a member of Ray Charles's band at the time, was an early and lasting influence on Sanborn.

Sanborn attended college at Northwestern University in Evanston, Illinois, directly north of Chicago and studied music. He transferred to the University of Iowa in Iowa City east of Des Moines where he played and studied with saxophonist J. R. Monterose.

Sanborn performed with blues musicians Albert King and Little Milton at the age of 14. In 1967 he took a Greyhound bus to San Francisco to join the "Summer of Love". While visiting recording studios he was invited to sit in on a session with The Paul Butterfield Blues Band. He made such an impression that he joined the band for five years. He recorded on four Butterfield albums as a horn section member and a soloist from 1967 to 1971. Early in the morning on August 18, 1969, he appeared with the band at the Woodstock Music Festival in Bethel, New York.

In 1972, Sanborn played on the track "Tuesday Heartbreak" on the Stevie Wonder album Talking Book. In 1975 he worked with David Bowie on Young Americans and on the James Taylor recording of "How Sweet It Is (To Be Loved by You)" on the album Gorilla. In the mid-1970s, Sanborn became active in the popular jazz fusion scene by joining the Brecker Brothers band, where he became influenced by Michael Brecker. While with the Brecker brothers, he recorded his first solo album, Taking Off, which became a jazz/funk classic. In 1985, Sanborn and Al Jarreau played two sold-out concerts at Chastain Park in Atlanta. Although Sanborn was most associated with smooth jazz, he studied free jazz in his youth with saxophonists Roscoe Mitchell and Julius Hemphill. In 1993, he revisited this genre when he appeared on Tim Berne's Diminutive Mysteries, which was dedicated to Hemphill, who was Berne's mentor. Sanborn's album Another Hand featured avant-garde musicians.

He found life on the road increasingly difficult but continued to tour. In 2017, despite plans to reduce his workload to no more than 150 gigs a year, he embarked on a tour which included Istanbul and Nairobi, Kenya.