Colombia is a unitary republic made up of thirty-two administrative divisions referred to as departments (Spanish: departamentos, sing. departamento) and one Capital District (Distrito Capital). Departments are country subdivisions and are granted a certain degree of autonomy. Each department has a governor (gobernador) and an Assembly (Asamblea Departamental), elected by popular vote for a four-year period. The governor cannot be re-elected in consecutive periods.

Departments are formed by a grouping of municipalities (municipios, sing. municipio). Municipal government is headed by mayor (alcalde) and administered by a municipal council (concejo municipal), both of which are elected by popular vote for four-year periods.

The current borders and number of the departments of Colombia was finally set after the 1991 Colombian Constitution came into effect. Before that, the number of departments went from the original nine federal states of the United States of Colombia who ratified the Constitution of 1863 (Antioquia, Bolívar, Boyacá, Cauca, Cundinamarca, Magdalena, Panamá, Santander and Tolima) to the current 32 departments that exist in the present-day Republic of Colombia.

All departments of Colombia are further subdivided into various municipalities, which represent smaller areas of the department and are often, but not always, coterminous with the urban and rural limits of a given city or town. Some municipalities might also include smaller towns or hamlets (known as corregimientos in Spanish), within the borders of the wider municipality. The rural subdivisions of municipalities are know in Spanish as veredas.

Most departments also group various municipalities into regions which are larger than a municipality and are usually known as either provinces or subregions. These subdivisions work as an intermediate level subnational regions between a department and a municipality. However, this provinces or subregions do not feature in the 1991 Colombian Constitution and are thus defined instead by the departmental governments and assemblies.

The indigenous territories are at the third level of administrative division in Colombia, as are the municipalities. Indigenous territories are created by agreement between the government and indigenous communities. In cases where indigenous territories cover more than one department or municipality, local governments jointly administer them with the indigenous councils, as set out in Articles 329 and 330 of the Colombian Constitution of 1991. Also indigenous territories may achieve local autonomy if they meet the requirements of the law.

Article 329 of the 1991 constitution recognizes the collective indigenous ownership of indigenous territories and repeats that are inalienable. Law 160 of 1994 created the National System of Agrarian Reform and Rural Development Campesino, and replaced Law 135 of 1961 on Agrarian Social Reform; it establishes and sets out the functions of INCORA, one of the most important being to declare which territories will acquire the status of indigenous protection and what extension of existing ones will be allowed. Decree 2164 of 1995 interprets Law 160 of 1994, providing, among other things, a legal definition of indigenous territories.

Indigenous territories in Colombia are mostly located in the departments of Amazonas, Cauca, La Guajira, Guaviare, and Vaupés.