Destination Moon (French: Objectif Lune) is the sixteenth volume of The Adventures of Tintin, the comics series by Belgian cartoonist Hergé. The story was initially serialised weekly in Belgium's Tintin magazine from March to September 1950 and April to October 1952 before being published in a collected volume by Casterman in 1953. The plot tells of young reporter Tintin and his friend Captain Haddock who receive an invitation from Professor Calculus to come to Syldavia, where Calculus is working on a top-secret project in a secure government facility to plan a crewed mission to the Moon.

Developed in part through the suggestions of Hergé's friends Bernard Heuvelmans and Jacques Van Melkebeke, Destination Moon was produced following Hergé's extensive research into the possibility of human space travel – a feat that had yet to be achieved – with the cartoonist seeking the work to be as realistic as possible. During the story's serialisation, Hergé established Studios Hergé, a Brussels-based team of cartoonists to aid him on the project. Hergé concluded the story arc beginning in this volume with Explorers on the Moon, while the series itself became a defining part of the Franco-Belgian comics tradition. Critics have held the illustrative detail of the book in high esteem, but have expressed divided opinions of the story; some consider it to be among the most mature and emotionally resonant entries in the series, while others fault it for downplaying the humour seen in previous volumes in favour of the scientific focus of the narrative. The story was adapted for the 1957 Belvision animated series Hergé's Adventures of Tintin, the 1989 computer game Tintin on the Moon, the 1991 Ellipse/Nelvana animated series The Adventures of Tintin, and the 1992–93 BBC Radio 5 dramatisation of the Adventures.

Tintin, Snowy, and Captain Haddock travel to join Professor Calculus, who has been commissioned by the Syldavian government to secretly build a spacecraft that will fly to the Moon. Arriving at the Sprodj Atomic Research Centre, they meet the Centre's managing director, Mr. Baxter, and Calculus' assistant, the engineer Frank Wolff. After witnessing Calculus test a new multiplex helmet for the planned mission, they are informed both of his plan and of his new use of an ear trumpet owing to his signature hearing ailments. Haddock is against the plan, but Calculus, accidentally swapping Haddock's pipe for the ear trumpet, believes instead that he agreed; later, Haddock accidentally almost burns the ear trumpet mistaking it for his pipe.

An uncrewed sub-scale prototype of the rocket – the "X-FLR6" – is launched on a circumlunar mission to photograph the far side of the Moon and test Calculus's nuclear rocket engine. Before the launch, the Centre's radar picks up a plane which drops three paratroopers near to the centre. One of the men dies from a malfunctioning parachute; the incident coincides with the arrival of the police detectives Thomson and Thompson, who are initially believed to be the intruders.

Tintin sets out to locate the spies, telling Haddock to follow from the base, as he suspects a mole is on the inside. Wolff follows Haddock out of suspicion. Tintin catches one of the paratroopers during an exchange at an air vent, but is shot by the other before he is able to do anything. Simultaneously, the base experiences a temporary power outage, and confusion ensues, with neither Haddock (who passed out) nor Wolff (who was grabbed by the detectives) capable of explaining clearly what happened.

This incident confirms the Centre's suspicions that the paratroopers were agents of a foreign power, but Tintin fears that efforts to trace any leaked information would be futile. The rocket is successfully launched and orbits the Moon as planned, but on its return it is intercepted by the aforementioned foreign power, who have used the leaked information concerning the rocket's radio control. However, Tintin had anticipated this and had asked Calculus to rig a self-destruct mechanism for the rocket; the Centre is thus able to destroy the rocket to prevent it from falling into enemy hands. Tintin reasons that there must have been an inside spy who leaked information to the paratroopers, but no suspects are found.

Preparations are made for the crewed expedition to the moon. Calculus is infuriated when Haddock accuses him of "acting the goat" and gives his friends a forced tour of the Moon rocket. However, after telling the Captain to look where he's going ("Stars above, Captain! Behind you!"), Calculus forgets to look where he is going, falls down a ladder, and suffers amnesia. When Calculus' memory fails to return, Haddock proposes a violent shock as a solution, but his increasingly insane attempts repeatedly backfire. Eventually, after repeating the phrase "you can keep acting the goat as long as you like", Haddock successfully, though accidentally, triggers Calculus' memory recovery.

Calculus is able to complete construction of the rocket and final preparations are made, with Calculus obtaining a proper hearing aid for near-perfect hearing of transmission signals. On the night of the launch, Haddock initially backs out, but after hearing Thomson and Thompson stating that he would be too old to go, he angrily declares his participation. The crew finally board the rocket, and later lose consciousness as the rocket successfully takes off due to the sudden g-force. Despite attempting to make contact, the ground crew are unable to get through, and the book ends with the rocket flying towards the Moon while the ground crew repeatedly calls, "Earth calling Moon Rocket, are you receiving me?".