Dharmapasha (Bengali: ধর্মপাশা, romanized: Dhormopasha, also spelled as Dharampasha or Dharamapasha, is an upazila of Sunamganj District in the Division of Sylhet, Bangladesh.

Dharamapasha is located at 24°54′00″N 91°01′00″E / 24.9000°N 91.0167°E / 24.9000; 91.0167. It has 25,305 households and total area 310.00 km². It is located on the banks of the Kangsha River, close to the haor areas. Tānguār Hāor, the largest haor of Bangladesh, lies between the upazilas of Dharmapasha and Tahirpur. Other haors, rivers and beels in Dharmapasha include Surma River, Tagār Hāor, Dhārām Hāor, Ghāglājur River, Sārdā Bil, Kaimer Dair, Dhānkuniyā Hāor, Sonāmaral Hāor, Rāuwār Bil, Shiyāldighā Bil, Pākertalā Bil, Phirāgāng Bil, Dharani Bil, Jāldharā Bil, Sanuā Hāor, Pashwa River, Chhātidharā River, Rāklā River, Baulāi River, Chepta River, Nowanadi River and Helainna River.

The neighbouring upazilas are Mohanganj, Barhatta, Kalmakanda, Jamalganj and Tahirpur.

During the reign of the Mughal emperor Aurangzeb in around 1691, Mahamanikya Datta of Hooghly set off for Assam. On his journey, he passed by the Kalidaha lowlands and was astonished by its natural beauty. As a result, he purchased a jagir in Sukhair in present-day Dharmapasha. In 1695, Zamindar Mohanlal had a large palace built within the Sukhair jagir, and they had authority over 20 wetlands. An English officer visited the Tanguar haor for tiger hunting during the zamindari of Maiyuk Chaudhuri. The English officer was captured by three tigers, and when news of this reached the Zamindar, he broke the law by shooting the tigers to free him. Chaudhuri was later awarded a gun for his services. The reason for the change of surname from Datta to Rai-Chaudhuri is explained by Malay Rai Chaudhuri to be due to the fact that one of his ancestors married a Das when arriving to Sukhair. Mahamanikya Dutta's fourth descendant Pratap Rai-Chaudhuri embraced Islam and married a woman from an upper-class Muslim family in nearby Rajapur. He inherited half of Sukhair's zamindari, and later became the Zamindar of Rajapur.

In 1787, the Khasis of Laur rebelled against the British East India Company by plundering many of their parganas (including modern-day Dharmapasha Upazila's Bangsikunda, Ramdigha, and Selbaras) and killing up to 800 people. The British collector of Sylhet, Robert Lindsay, sent troops to the area but before they could arrive, the Khasis had retreated back to their mountains.

Muhammad Akhtar Chowdhury Tota Mia (b. 1840s), the zamindar of Selbarash, was renowned for his bravery. In the early 20th century, the deputy commissioner of Sylhet described the zamindars of Selbarash as among the most prominent landholders of greater Sylhet. Narrative folk ballads, known as pala gan, about Tota Mia's heroism gained prominence. These ballads are preserved in Badiuzzaman's Momenshahi Geetika published by Bangla Academy.

On 12 June 1897, the area was heavily affected during an earthquake which resulted in many deaths. Between 1922 and 1923, Sukhair became a prominent area of the Nankar Rebellion. Ghulam Jilani Choudhury of the Selbaras zamindar family married Ashrafunnesa Choudhurani in the 1930s. Their son, Ahmad Taufiq Choudhury, joined the Ahmadiyya movement where he became the regional leader of Khuddam-ul Ahmadiyya, and later migrated to Mymensingh where he became the Ameer of Ahmadiyya Muslim Jamaat Bangladesh after independence.

In 1942, a thana was established at Dharmapasha. 50 people died of smallpox in one night at the village of Bishara in 1967. In 1983, Dharmapasha Thana was upgraded to an upazila (sub-district) as part of the President of Bangladesh Hussain Muhammad Ershad's decentralisation programme. Three years later, a second thana was founded in Dharmapasha Upazila called Madhyanagar Thana. On 26 July 2021, Khandker Anwarul Islam announced the establishment of Madhyanagar Upazila, which effectively reduced the Dharmapasha Upazila.