Dona Bertarelli (born 1968) is a Swiss entrepreneur, philanthropist and ocean advocate. She is co-chair of the Bertarelli Foundation, founder of Sails of Change, co-founder of the Pew Bertarelli Ocean Legacy and founder of Global Fishing Watch Marine Manager. She is a Patron of Nature of the IUCN. As a sailor, she is the winner of the 2010 and 2014 Bol d'Or Mirabaud and, with her team Spindrift Racing, the Fastnet Race in 2013. In the same year, she and her team also broke the record for the America Discovery Route. In the winter 2016 she completed the Jules Verne Trophy challenge.

In 2023 she was distinguished as a Knight of the National Order of the Legion of Honour of France and as a Commander of the national Order of Honorato Vásquez of Ecuador.

Bertarelli was born in Rome on 3 March 1968. She is the daughter of Maria Iris Bertarelli and Fabio Bertarelli. She and her brother Ernesto inherited Serono, a biotechnology company. Serono was founded in 1906 in Rome and was the building block of the family's wealth. The family now has several activities and investments, with interests in areas such as finance, real estate, health, sports, hospitality or agriculture. According to Forbes magazine, she is ranked as the 486th wealthiest person in the world with an estimated net worth of $6.2 billion, as of June 2024^[update].

Bertarelli has a BSc from Boston University's College of Communication.

Bertarelli was active in Serono, the family business, and from 1992 to 1997 was Executive Director, Public and Professional Affairs, where she established the Serono Symposia and the Serono Foundation. The company was sold to Merck KGaA at the beginning of 2007.

The five-star Grand Hôtel Park in Gstaad was taken over by Bertarelli in 2003. In January 2025, it was announced the hotel would be managed by Four Seasons after a complete renovation.

She became a special adviser to UNCTAD in June 2020.

In late 2022, Bertarelli acquired Italian fashion brand Fiorucci.