The Dust Brothers were a pair of songwriters and producers consisting of E.Z. Mike (Michael Simpson) and King Gizmo (John King). They were famous for the sample-based music they produced in the 1980s and 1990s, and specifically for their work on the albums Paul's Boutique by Beastie Boys, Odelay, Midnite Vultures and Guero by Beck, the soundtrack to Fight Club, and "MMMBop" by Hanson. They were based in Los Angeles, California.

Michael "E.Z." Simpson and John "Gizmo" King started working together as the Dust Brothers in 1985 at Pomona College radio station, KSPC, hosting a weekly hip-hop show called The Big Beat Showcase.

They developed writing and producing skills creating music for their show and DJing and rapping at parties. In 1987, they began writing and producing for the Delicious Vinyl label. There they wrote and produced tracks on Tone Lōc's album, Lōc-ed After Dark, Young MC's debut album Stone Cold Rhymin', and other Delicious Vinyl releases. They also worked with the Boo Yaa Tribe on the album New Funky Nation, producing several songs on that album.

Mike D of the Beastie Boys stopped by mutual friend Matt Dike's apartment, where Simpson and Dike played music intended to be a Dust Brothers album, and liked what he heard. The Dust Brothers along with Dike ended up co-writing, producing and mixing the Beastie Boys' second album, Paul's Boutique, considered one of the best albums of all time by Time in 2006.

Beck had the Dust Brothers produce his album Odelay, released in 1996. The album spawned the hits "Where It's At" (No. 61 on the Hot 100), "Devils Haircut" (No. 94 on the Hot 100), "The New Pollution" (No. 78) and "Jack-Ass" (No. 73). In 1995 the Dust Brothers co-produced Mötley Crüe frontman Vince Neil's second solo album Carved in Stone.

In 1997, they produced a track with Korn called "Kick the P.A." for the Spawn soundtrack; produced the number one hit "MMMBop" for Hanson's first major label album Middle of Nowhere; and created a song on the number one soundtrack to the Howard Stern film Private Parts named "Tortured Man", featuring vocals by Stern. The Dust Brothers also co-produced three songs on the Rolling Stones album, Bridges to Babylon.

The next year, the duo were approached by director David Fincher to assemble the score for the film Fight Club, including "This Is Your Life", a song featuring lines from the film, including a monologue by the character Tyler Durden (Brad Pitt). The same year also saw the Dust Brothers collaborate with Jeymes Samuel aka the Bullitts on the soundtrack for the film Muppets from Space, recording a cover version of the Earth, Wind & Fire song "Shining Star".

In 1999, the two collaborated with Carlos Santana and Eagle-Eye Cherry on the track "Wishing It Was" which appeared on Santana's multi-platinum album Supernatural. For that album they won their first Grammy, after having received numerous nominations for their past work with Beck and with Hanson, and as artists for their instrumental song on the X-Files soundtrack. They also recorded, produced and mixed an album by 'hip pop' group 10 Cents named Buggin Out, and remixed the Styles of Beyond track "Winnetka Exit".