Dynamo is a set of techniques that together can form a highly available key-value structured storage system or a distributed data store. It has properties of both databases and distributed hash tables (DHTs). It was created to help address some scalability issues that Amazon experienced during the holiday season of 2004. By 2007, it was used in Amazon Web Services, such as its Simple Storage Service (S3).

Amazon DynamoDB is "built on the principles of Dynamo" and is a hosted service within the AWS infrastructure. However, while Dynamo is based on leaderless replication, DynamoDB uses single-leader replication.

Amazon published the paper on Dynamo, but never released its implementation. The index layer of Amazon S3 implements and extends many core features of Dynamo. Since then, several implementations have been created based on the paper. The paper also inspired many other NoSQL database implementations, such as Apache Cassandra, Project Voldemort and Riak.