Dominick Edward Blake PC KC (October 13, 1833 – March 1, 1912), known as Edward Blake, was the second premier of Ontario, from 1871 to 1872 and leader of the Liberal Party of Canada from 1880 to 1887. He is one of three federal permanent Liberal leaders never to become Prime Minister of Canada, the others being Stéphane Dion and the latter's immediate successor Michael Ignatieff. He may be said to have served in the national politics of what developed as the affairs of three nationalities: Canadian, British, and Irish. Blake was also the founder, in 1856, of the Canadian law firm now known as Blake, Cassels & Graydon LLP.

After retiring from Canadian politics, Blake served four terms as an MP in the United Kingdom Parliament representating the Irish National Federation and then the Irish Parliamentary Party.

Blake was born in 1833, in Adelaide Township, Middlesex County, Upper Canada, the son of William Hume Blake and Catherine Honoria Hume, and was educated at Upper Canada College.

In 1856, after Blake was called to the bar, he entered into partnership with Stephen M. Jarvis in Toronto to practice law. When his brother Samuel Hume Blake joined soon thereafter, the firm became Blake & Blake. Today it is known as Blake, Cassels & Graydon.

As a consequence of the ruling of the Judicial Committee of the Privy Council in Long v The Bishop of Cape Town, Blake offered a legal opinion to Benjamin Cronyn (then Bishop of the Anglican Diocese of Huron) on the legality of the convening of a Provincial Synod of the various Dioceses of the Ecclesiastical Province of Canada by Francis Fulford (then Bishop of Montreal and Metropolitan of Canada). He determined that the concurrence of all of the Dioceses of the Ecclesiastical Province would be required prior to the creation of the Provincial Synod, and therefore no such Synod could legally be convened until the entity first existed. This opinion was read into the Minutes of the seventh session of the Synod of the Diocese of Huron which convened in June 1864.

Blake was recruited into active politics by George Brown, elected Member of the Provincial Parliament (Durham West and Bruce South) became leader of the Ontario Liberal Party in 1868 and premier in 1871, but left provincial politics to run in the 1872 federal election, in which he was re-elected. The "dual mandate" rule that allowed a politician to sit simultaneously in a provincial and federal house had been abolished, and Blake chose to abandon his career in provincial politics. He played a major role in exposing the government of Sir John A. Macdonald's complicity in the Pacific Scandal forcing the government's resignation. Blake was offered the prime ministership, but turned it down due to ill health.

When the Liberals won the subsequent 1874 federal election, Blake joined the cabinet of Prime Minister Alexander Mackenzie and served as Minister of Justice and President of the Queen's Privy Council for Canada.

From 1876 to 1900, he was the chancellor of the University of Toronto.