The Endocrine Society is a professional, international medical organization in the field of endocrinology and metabolism, founded in 1916 as The Association for the Study of Internal Secretions. The official name of the organization was changed to the Endocrine Society on January 1, 1952. It is a leading organization in the field and publishes four leading journals. It has more than 18,000 members from over 120 countries in medicine, molecular and cellular biology, biochemistry, physiology, genetics, immunology, education, industry, and allied health. The Society's mission is: "to advance excellence in endocrinology and promote its essential and integrative role in scientific discovery, medical practice, and human health."

It is said to be "the world's oldest, largest and most active organization devoted to research on hormones and the clinical practice of endocrinology."

Annual meetings have been held since 1916 except in 1943 and 1945 during World War II when meetings were cancelled at the request of the United States government. Realizing the increasing importance of endocrinology to general medicine, the Council, in 1947, established an annual postgraduate assembly now known as the Clinical Endocrinology Update.

The Society publishes Endocrinology, the first issue of which was published in January 1927 and edited by Henry Harrower. Another publication, The Journal of Clinical Endocrinology (JCEM), was established in 1941, and the name of the journal was changed to The Journal of Clinical Endocrinology & Metabolism on January 1, 1952. Current publications include: Endocrine Reviews, JCEM Case Reports, and Journal of the Endocrine Society (JES).

Each year, the Endocrine Society hosts three major meetings throughout the course of a calendar year: ENDO, Clinical Endocrinology Update (CEU), and Endocrine Board Review (EBR). ENDO is the top global meeting on endocrinology research and clinical care. This annual conference gathers world-renowned speakers in the endocrine space to showcase cutting-edge science.

Clinical Endocrinology Update (CEU) provides practicing endocrinologists with the latest updates through the latest expert guidelines in hormone care.

Endocrine Board Review (EBR) is the leading online training program for fellows, residents, and physicians preparing for board certification exams. EBR offers a comprehensive preparation course for the Endocrinology, Diabetes, & Metabolism Exam.

The Endocrine Society influences a wide range of policies affecting endocrine-related research and practice.