The fourteenth-generation Ford F-Series is a range of pickup trucks produced by Ford, introduced for the 2021 model year. This was the first generation to include a fully-electric and hybrid pickup truck among the offerings, with the F-150 Lightning EV having entered production in 2022. The F-150 is positioned above the mid-size Ranger but below the larger Super Duty in the Ford truck lineup.

Sharing a strong visual resemblance to the previous generation, the 2021 F-150 underwent a redesign of 92% of its parts, carrying over only its cab, pickup box structure, and font design (including the tailgate script). The bed and cab configurations remain the same: regular cab and SuperCab (extended cab) trucks are available with 6.5-and-8-foot (2.0 and 2.4 m) beds, while SuperCrew (crew cab) trucks are available with 5.5-and-6.5-foot (1.7 and 2.0 m) boxes (the SuperCab with the 8-foot (2.4 m) box was dropped for 2024). Along with exterior design changes to enhance aerodynamics, many changes were made to the interior, adding fold-flat front seats and larger touchscreens (including a fully digital instrument panel on higher-end trims; now on all trims starting in the 2024 refresh).

The powertrain line is largely carried over from the previous generation, with a 3.3 L V6, 2.7 L and 3.5 L EcoBoost twin-turbo V6s, a 5.0 L V8, and a 3.0 L turbo-diesel V6. However, the 5.0 L V8 receives a new cylinder deactivation system, called Variable Displacement Engine technology, similar to GM's Active Fuel Management and Chrysler's Multi-Displacement System. All engines are paired to the ten-speed 10R80 automatic transmission. New for this generation of F-150 is a gasoline–electric hybrid powertrain. Dubbed PowerBoost, this powertrain is the first to be offered in a Ford pickup truck, pairing an electric motor with the 3.5 L V6 EcoBoost engine. The fourteenth generation F-150 is considered the first full-size true hybrid truck since GM's CVT-only Silverado/Sierra 1500 Hybrid was last offered in 2013.

Added to the lineup was a new Tremor trim level (the name derived from that of the Super Duty line and originally used as a special sport trim package for the 2014 F-150).

Available only with the SuperCrew cab configuration, the hybrid version of the F-150, called the PowerBoost, combines a 3.5 L EcoBoost V6 with a 47 hp (35 kW) hybrid motor/generator between the engine and transmission. A 1.5 kWh lithium-ion battery pack is located under the bed. The net gain is 47 hp (35 kW) and 70 lb⋅ft (95 N⋅m). The electrical power also allowed Ford to have up to 7.2 kW in the bed of a truck, far exceeding the capacity of a normal 120 V receptacle. A 20 percent fuel economy increase over a base 3.5 L EcoBoost has been observed at combined city/highway driving. Depending on the trim, the hybrid option added at least $2,500 to the base price. All PowerBoost models receive a badge on the bottom of both front doors, and are assembled exclusively at the Dearborn Truck Plant in Dearborn, Michigan.

For 2024, the PowerBoost system has been updated with a simpler design. Both starters—one on the engine and the other integrated into the accessory belt drive—have been eliminated in favor of a mechanism that uses the transmission to start the engine via a hybrid motor. This change was made possible by the data and insights gathered from the launch model, combined with over 300 software enhancements. Additionally, all PowerBoost models now come standard with four-wheel drive, and the hybrid powertrain could be had at no cost over the 3.5 L non-hybrid EcoBoost engine.

Specifications:

Ford unveiled an electric version of the Ford F-150 called the F-150 Lightning, reviving the model name for the first time since the previous Lightning was discontinued after the 2004 model year (and 2004 concept). It debuted on May 19, 2021, and deliveries to customers began in May 2022. The F-150 Lightning has dual motors. It is built at the new Ford Rouge Electric Vehicle Center in Michigan.