The Ford E-Series (also marketed as the Ford Econoline and Ford Club Wagon) is a range of full-size vans produced by the Ford Motor Company since 1961. Introduced as a replacement for the Ford F-Series panel van, the line has spanned four generations. Sold in both retail and commercial markets, the E-Series has been offered as passenger and cargo vans, as well as in cutaway and stripped-chassis configurations.

With over 8.2 million units sold since 1961, the Ford E-Series is the third-best selling van line in history (outranked only by the Ford Transit and Volkswagen Transporter). Ford retired the E-Series passenger and cargo vans after the 2014 model year, replacing them with the Ford Transit. The E-Series continues to be offered only in cutaway and stripped-chassis configurations.

The E-Series is assembled at Ohio Assembly in Avon Lake, Ohio, which has produced the E-Series since 1975. Before its closure in 2005, Lorain Assembly in Lorain, Ohio, built the model line from its launch in 1961. In 2021, it became the second active Ford model line to reach 60 years of continuous production.

Ford released the first-generation Ford Econoline on September 21, 1960, for the 1961 model year. Beginning development in 1957, the model line served as a replacement for the Ford F-Series panel delivery (and the smaller Ford Courier sedan delivery). Three models were available, a cargo van, a passenger van (also sold under the Station Bus and Club Wagon names), and a forward-control pickup truck.

Competing directly against the rear-engined Chevrolet Corvair van and Volkswagen Transporter, the Ford Econoline established multiple design precedents adopted by successive North American vans, including the Chevrolet Van and Dodge A100. While also a forward-control vehicle, Ford introduced a midengined configuration. To improve cargo access by creating a flat load floor and enlarging the rear doors, the engine was placed between the front seats.

The first-generation Ford Econoline was based on the Ford Falcon compact car range. To accommodate its 90-inch wheelbase (the shortest for a Ford since 1908), the Econoline adopted a midengined configuration, placing the engine behind the front axle; consequently, the layout precluded the use of a V8 engine.

The Econoline was initially powered by the 85 hp (63 kW) 144-cubic-inch inline-six (the standard engine of the Falcon); a 101 hp (75 kW) 170-cubic-inch inline-six was introduced as an option. For 1965, the 170 six became standard, with a 240 cubic-inch six introduced as an option. A three-speed manual was standard, with a Dagenham four-speed manual introduced for 1963 and discontinued in 1964; the 170-cubic-inch engine was offered with a three-speed automatic in 1964, and the larger two engines were both offered with a three-speed automatic as an option thereafter.

In contrast to the Falcon, the Econoline was fitted with a solid front axle and a solid rear axle suspension with leaf springs for all four wheels.