As of 2024^[update], there have been 32 drivers from Switzerland who have entered Formula One World Championship Grands Prix motor races, with 23 of them having started a race.

Switzerland's first Formula One driver was Emmanuel 'Toulo' de Graffenried who participated in 23 Grands Prix making his debut at the first Formula One Championship Grand Prix. His career spanned the first 7 seasons of Formula One. He managed to score points in 4 races with a best result of 4th in the 1953 Belgian Grand Prix.

Toni Branca made his debut in his home Grand Prix of 1950, finishing 11th. He also competed in the 1950 Belgian Grand Prix and the 1951 German Grand Prix, finishing 10th in the former and retiring with engine failure in the latter.

Rudi Fischer was the first Swiss driver to reach the podium in Formula One. Despite only starting 7 Grands Prix he made the podium twice; with 2nd in Switzerland and 3rd in Germany, both in 1952. Those were his only points finishes.

Switzerland's next driver was Peter Hirt. He entered five races in the early 1950s, culminating in three retirements, a 7th place and an 11th-place finish.

Rudolf Schoeller participated in one race; the 1952 German Grand Prix, he retired on lap three with suspension issues.

Max de Terra entered his home Grands Prix of 1952 and 1953, he retired from the former and finished 8th in the latter.

Albert Scherrer also only entered one race, the 1953 Swiss Grand Prix, he finished 16 laps down and unclassified in his customer HWM.