GRIK5

GRIK5
Identifiers
Aliases	GRIK5, EAA2, GRIK2, GluK5, KA2, glutamate ionotropic receptor kainate type subunit 5
External IDs	OMIM: 600283; MGI: 95818; HomoloGene: 1578; GeneCards: GRIK5; OMA:GRIK5 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	42,070,206 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	25,072,346 bp
RNA expression pattern
	Top expressed in
	olfactory bulb; ; lateral nuclear group of thalamus; ; ventral tegmental area; ; subthalamic nucleus; ; vena cava; ; superior vestibular nucleus; ; inferior ganglion of vagus nerve; ; pons; ; external globus pallidus; ; pars compacta;
	Top expressed in
	superior frontal gyrus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; entorhinal cortex; ; perirhinal cortex; ; CA3 field; ; neural layer of retina; ; olfactory tubercle; ; ventricular zone; ; primary motor cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	glutamate receptor activity; PDZ domain binding; kainate selective glutamate receptor activity; SH3 domain binding; ion channel activity; ionotropic glutamate receptor activity; identical protein binding; extracellularly glutamate-gated ion channel activity; ligand-gated ion channel activity; signaling receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	integral component of membrane; perikaryon; postsynaptic membrane; kainate selective glutamate receptor complex; membrane; postsynaptic density; synapse; cell junction; terminal bouton; axon; dendrite; soma; endoplasmic reticulum; neuron projection; ionotropic glutamate receptor complex; presynaptic membrane; nucleus; plasma membrane; hippocampal mossy fiber to CA3 synapse; glutamatergic synapse; integral component of postsynaptic membrane; integral component of presynaptic membrane; integral component of postsynaptic density membrane;
Biological process	synaptic transmission, glutamatergic; regulation of membrane potential; ion transport; receptor clustering; protein retention in ER lumen; regulation of synaptic vesicle fusion to presynaptic active zone membrane; ion transmembrane transport; positive regulation of neuron apoptotic process; establishment of localization in cell; ionotropic glutamate receptor signaling pathway; excitatory postsynaptic potential; cellular response to glucose stimulus; chemical synaptic transmission; modulation of chemical synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	2901
	14809
	ENSG00000105737
	ENSMUSG00000003378
	Q16478
	Q61626
	NM_001301030; NM_002088
	NM_008168; NM_001360067
	NP_001287959; NP_002079
	NP_032194; NP_001346996; NP_001389776; NP_001389777; NP_001389778
	Wikidata
View/Edit Human	View/Edit Mouse

Glutamate receptor, ionotropic kainate 5 is a protein that in humans is encoded by the GRIK5 gene.^[5]^[6]

Function

This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members.^[6]

Interactions

GRIK5 has been shown to interact with DLG4^[7]^[8] and GRIK2.^[9]^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105737 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003378 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Szpirer C, Molne M, Antonacci R, Jenkins NA, Finelli P, Szpirer J, Riviere M, Rocchi M, Gilbert DJ, Copeland NG, et al. (January 1995). "The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat". Proc Natl Acad Sci U S A. 91 (25): 11849–53. Bibcode:1994PNAS...9111849S. doi:10.1073/pnas.91.25.11849. PMC 45333. PMID 7527545.
^ ^a ^b "Entrez Gene: GRIK5 glutamate receptor, ionotropic, kainate 5".
^ Mehta S, Wu H, Garner CC, Marshall J (May 2001). "Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97". J. Biol. Chem. 276 (19): 16092–9. doi:10.1074/jbc.M100643200. PMID 11279111.
^ Garcia EP, Mehta S, Blair LA, Wells DG, Shang J, Fukushima T, Fallon JR, Garner CC, Marshall J (October 1998). "SAP90 binds and clusters kainate receptors causing incomplete desensitization". Neuron. 21 (4): 727–39. doi:10.1016/S0896-6273(00)80590-5. PMID 9808460. S2CID 18723258.
^ Wenthold RJ, Trumpy VA, Zhu WS, Petralia RS (January 1994). "Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodies". J. Biol. Chem. 269 (2): 1332–9. doi:10.1016/S0021-9258(17)42262-9. PMID 8288598.
^ Ripellino JA, Neve RL, Howe JR (January 1998). "Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum". Neuroscience. 82 (2): 485–97. doi:10.1016/S0306-4522(97)00296-0. PMID 9466455. S2CID 23219004.

External links

GRIK5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105737 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003378 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7527545-5] Szpirer C, Molne M, Antonacci R, Jenkins NA, Finelli P, Szpirer J, Riviere M, Rocchi M, Gilbert DJ, Copeland NG, et al. (January 1995). "The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat". Proc Natl Acad Sci U S A. 91 (25): 11849–53. Bibcode:1994PNAS...9111849S. doi:10.1073/pnas.91.25.11849. PMC 45333. PMID 7527545.

[entrez-6] "Entrez Gene: GRIK5 glutamate receptor, ionotropic, kainate 5".

[pmid11279111-7] Mehta S, Wu H, Garner CC, Marshall J (May 2001). "Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97". J. Biol. Chem. 276 (19): 16092–9. doi:10.1074/jbc.M100643200. PMID 11279111.

[pmid9808460-8] Garcia EP, Mehta S, Blair LA, Wells DG, Shang J, Fukushima T, Fallon JR, Garner CC, Marshall J (October 1998). "SAP90 binds and clusters kainate receptors causing incomplete desensitization". Neuron. 21 (4): 727–39. doi:10.1016/S0896-6273(00)80590-5. PMID 9808460. S2CID 18723258.

[pmid8288598-9] Wenthold RJ, Trumpy VA, Zhu WS, Petralia RS (January 1994). "Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodies". J. Biol. Chem. 269 (2): 1332–9. doi:10.1016/S0021-9258(17)42262-9. PMID 8288598.

[pmid9466455-10] Ripellino JA, Neve RL, Howe JR (January 1998). "Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum". Neuroscience. 82 (2): 485–97. doi:10.1016/S0306-4522(97)00296-0. PMID 9466455. S2CID 23219004.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

GRIK5

GRIK5

GRIK5

Add your contribution

Hub overview

Root Wikipedia Article

GRIK5

Function

Interactions

See also

References

Further reading

External links