Gamma-ray burst progenitors are the types of celestial objects that can emit gamma-ray bursts (GRBs). GRBs show an extraordinary degree of diversity. They can last anywhere from a fraction of a second to many minutes. Bursts could have a single profile or oscillate wildly up and down in intensity, and their spectra are highly variable unlike other objects in space. The near complete lack of observational constraint led to a profusion of theories, including evaporating black holes, magnetic flares on white dwarfs, accretion of matter onto neutron stars, antimatter accretion, supernovae, hypernovae, and rapid extraction of rotational energy from supermassive black holes, among others.

There are at least two different types of progenitors (sources) of GRBs: one responsible for the long-duration, soft-spectrum bursts and one (or possibly more) responsible for short-duration, hard-spectrum bursts. The progenitors of long GRBs are believed to be massive, low-metallicity stars exploding due to the collapse of their cores. The progenitors of short GRBs are thought to arise from mergers of compact binary systems like neutron stars, which was confirmed by the GW170817 observation of a neutron star merger and a kilonova.

As of 2007, there is almost universal agreement in the astrophysics community that the long-duration bursts are associated with the deaths of massive stars in a specific kind of supernova-like event commonly referred to as a collapsar or hypernova. Very massive stars are able to fuse material in their centers all the way to iron, at which point a star cannot continue to generate energy by fusion and collapses, in this case, immediately forming a black hole. Matter from the star around the core rains down towards the center and (for rapidly rotating stars) swirls into a high-density accretion disk. The infall of this material into the black hole drives a pair of jets out along the rotational axis, where the matter density is much lower than in the accretion disk, towards the poles of the star at velocities approaching the speed of light, creating a relativistic shock wave at the front. If the star is not surrounded by a thick, diffuse hydrogen envelope, the jets' material can pummel all the way to the stellar surface. The leading shock actually accelerates as the density of the stellar matter it travels through decreases, and by the time it reaches the surface of the star it may be traveling with a Lorentz factor of 100 or higher (that is, a velocity of 0.9999 times the speed of light). Once it reaches the surface, the shock wave breaks out into space, with much of its energy released in the form of gamma-rays.

Three very special conditions are required for a star to evolve all the way to a gamma-ray burst under this theory: the star must be very massive (probably at least 40 Solar masses on the main sequence) to form a central black hole in the first place, the star must be rapidly rotating to develop an accretion torus capable of launching jets, and the star must have low metallicity in order to strip off its hydrogen envelope so the jets can reach the surface. As a result, gamma-ray bursts are far rarer than ordinary core-collapse supernovae, which only require that the star be massive enough to fuse all the way to iron.

This consensus is based largely on two lines of evidence. First, long gamma-ray bursts are found without exception in systems with abundant recent star formation, such as in irregular galaxies and in the arms of spiral galaxies. This is strong evidence of a link to massive stars, which evolve and die within a few hundred million years and are never found in regions where star formation has long ceased. This does not necessarily prove the collapsar model (other models also predict an association with star formation) but does provide significant support.

Second, there are now several observed cases where a supernova has immediately followed a gamma-ray burst. While most GRBs occur too far away for current instruments to have any chance of detecting the relatively faint emission from a supernova at that distance, for lower-redshift systems there are several well-documented cases where a GRB was followed within a few days by the appearance of a supernova. These supernovae that have been successfully classified are type Ib/c, a rare class of supernova caused by core collapse. Type Ib and Ic supernovae lack hydrogen absorption lines, consistent with the theoretical prediction of stars that have lost their hydrogen envelope. The GRBs with the most obvious supernova signatures include GRB 060218 (SN 2006aj), GRB 030329 (SN 2003dh), and GRB 980425 (SN 1998bw), and a handful of more distant GRBs show supernova "bumps" in their afterglow light curves at late times.

Possible challenges to this theory emerged recently, with the discovery of two nearby long gamma-ray bursts that lacked the signature of any type of supernova: both GRB060614 and GRB 060505 defied predictions that a supernova would emerge despite intense scrutiny from ground-based telescopes. Both events were, however, associated with actively star-forming stellar populations. One possible explanation is that during the core collapse of a very massive star a black hole can form, which then 'swallows' the entire star before the supernova blast can reach the surface.^{[citation needed]}

Short gamma-ray bursts appear to be an exception. Until 2007, only a handful of these events have been localized to a definite galactic host. However, those that have been localized appear to show significant differences from the long-burst population. While at least one short burst has been found in the star-forming central region of a galaxy, several others have been associated with the outer regions and even the outer halo of large elliptical galaxies in which star formation has nearly ceased. All the hosts identified so far have also been at low redshift. Furthermore, despite the relatively nearby distances and detailed follow-up study for these events, no supernova has been associated with any short GRB.