George Dickel is a brand of Tennessee whisky produced in Tullahoma, in Coffee County, Tennessee. Today owned by Diageo, the modern brand was introduced in 1964, though the distillery has a longer history. Whisky production and aging takes place at the Cascade Hollow Distillery, which offers tours to the public and is part of the American Whiskey Trail. George Dickel operates the second-largest distillery in Tennessee, selling 130,000 cases in 2013, while the largest is Jack Daniel's, which sold 11.5 million cases the same year.

The brand's labels use the traditional Scottish spelling of whisky, instead of the more common American English spelling: whiskey. According to the company, this is because Dickel believed his product to be as smooth and high in quality as the best Scotch whiskies.

George A. Dickel was born in Germany in 1818, and emigrated to the United States in 1844. He founded a retail business in Nashville, Tennessee, in the 1850s, and began selling liquor in 1861. After the Civil War, he operated a liquor store on South College Street in Nashville. In the late 1860s, he founded George A. Dickel and Company, a wholesaling firm which bought whiskey from regional distillers and distributed it in barrels, jugs and bottles. In 1871, Meier Saltzkotter, who had worked as a superintendent for Dickel, became a partner in the company. Victor Emmanuel Shwab (1847–1924), a brother-in-law of Dickel who had initially worked for the company as a bookkeeper, became a partner in 1881.

George A. Dickel and Company was selling whiskey produced in Cascade Hollow, near Normandy, Tennessee, by John F. Brown and F.E. Cunningham in the 1870s. In 1879, Matthew Sims, a local businessman, bought Brown's share of the operation. In 1883, another local businessman, McLin Davis (1852–1898), joined the partnership. Davis became the operation's distiller, and is credited with the whisky's recipe. By the early 1890s, Cascade Whisky was one of the more popular brands in the region. The Cascade label included the phrase, "Mellow as Moonlight", which was rooted in Davis's method of cooling mash at night.

Following an accident in 1886, Dickel's health declined, and Shwab gradually took control of the wholesaling firm's daily operations. In 1888, Shwab purchased Sims's share of the Cascade Distillery, whose whiskey Dickel and Company had been selling for years. The terms of the purchase made Dickel and Company the sole distributor of Cascade. Shwab also purchased the popular Climax Saloon in Nashville, and afterward advertised the saloon as the "headquarters" of Cascade Whisky. After Davis's death in 1898, his son, Norman Davis, briefly ran the distillery, but was sued by Shwab and forced to sell his share in the operation.

Following Dickel's death in 1894, his share of Dickel and Company was willed to his wife, Augusta. Though he had advised her to sell out, she retained her share of the company, but did not participate in its operations. Upon her death in 1916, she willed her share to Shwab.

Throughout the early 1900s, Shwab fought vehemently against the rising calls for prohibition, spending thousands of dollars on lobbying campaigns in Nashville, and thwarting legislation aimed at curtailing the sale of alcohol on at least one occasion. In spite of his efforts, Tennessee enacted prohibition in 1910, forcing the Cascade operation to relocate to the Stitzel Distillery in Louisville, Kentucky. It was produced here until Kentucky enacted statewide prohibition in 1917. The operation shut down altogether with the onset of nationwide prohibition in 1920.

In 1933, national prohibition was repealed. Four years later, Shwab's heirs sold the Cascade brand to the Schenley Distilling Company. The recipe had never been written down, and had to be obtained from two former distillers at the Cascade Hollow site. In the 1940s and 1950s, Schenley's product, produced at the OFC Distillery in Frankfort, Kentucky, was marketed as Geo. A. Dickel's Cascade Kentucky Straight Bourbon Whisky.