The Government Palace (Spanish: Palacio de Gobierno), also known as the House of Pizarro (Spanish: Casa de Pizarro), is the seat of the executive branch of the Peruvian government, and the official residence of the president of Peru. The palace is a stately government building, occupying the northern side of the Plaza Mayor in Peru's capital city, Lima. Set on the Rímac River, the palace occupies the site of a very large huaca ("revered object") that incorporated a shrine to Taulichusco, the last kuraka (indigenous governor) of Lima.

The first Government Palace was built by Francisco Pizarro, governor of New Castile, in 1535. When the Viceroyalty of Peru was established in 1542, it became the viceroy's residence and seat of government as the Viceregal Palace (Spanish: Palacio Virreinal; Palacio de los Virreyes), also known as the Casas Reales. The most recent alterations to the building were completed in the 1930s, under the direction of President Oscar R. Benavides during his second term of office. The chief architects were Claude Antoine Sahut Laurent and Ricardo de Jaxa Malachowski.

A number of ceremonial guard units of the Peruvian Armed Forces are stationed at the palace, and participate in the daily Changing of the Guard ceremony and other official duties.

A large huaca ("revered object") stood on the present site of the palace, where Taulichusco, the last kuraka or indigenous ruler of the Rimac Valley, had lived until Francisco Pizarro's conquest of the area. Present-day Lima is built over the location of more than 300 sacred huaca sites, of which this was one of the most important.

Francisco Pizarro, appointed Governor of New Castile in 1529, founded the city of Lima as his capital in 1535 and built his palace on its Plaza Mayor in 1536. The first house was a two-story adobe structure, built on the Castilian model with two large courtyards for troops and stables. The building served as the head office of Pizarro's administration. On Sunday 26 June 1541, thirteen supporters of Diego de Almagro II, whose father Diego de Almagro had been executed in 1538 by Pizarro's brother Hernando, stormed the building. Several guests escaped as the attackers fought their way in, but four defenders were killed and four wounded before Pizarro was assassinated.

Following Pizarro's death in 1541, and the creation of the Viceroyalty of Peru in 1542, the building became the Viceregal Palace. It underwent several extensions over the course of this period, and was occupied by 43 viceroys before the last, José de la Serna, was forced out in 1821.

The building was damaged by an earthquake on 20 October 1687, and again in 1746. Antonio de Ulloa described the building as it was at the time of his arrival in Lima as a young lieutenant of the Spanish Navy in 1740:

In the north side of the square is the vice-roy's palace, in which are the several courts of justice, together with the offices of revenue, and the state prison. This was formerly a very remarkable building, both with regard to its largeness and architecture, but the greatest part of it being thrown down by the dreadful earthquake with which the city was visited, Oct. 20th, 1687, it now consists only of some of the lower apartments erected on a terras [sic], and is used as the residence of the vice-roy and his family.