Grabow (Meckl) station is located on the Berlin–Hamburg railway in Grabow in the south west of the German state of Mecklenburg-Vorpommern. Together with four other stations, which also opened on 15 October 1846, it is the oldest station in the state. The Neoclassical entrance building, which dates from the opening of the line, and some other buildings in the station area are heritage-listed.

The station is located in the town of Grabow in the district of Ludwigslust-Parchim, seven kilometres from the railway junction of Ludwigslust. It is located at kilometre 163.2 of the Berlin–Hamburg railway and is the last station in Mecklenburg before the border with Brandenburg. The station is about 500 metres northeast of the city centre. The railway crosses the river Elde southeast of the station.

Planning began for the construction of a railway line between Berlin and Hamburg around 1840. Different options were discussed. In Hamburg, a route running from Wittenberge south of the Elbe was favoured. There were several possible routes north of the Elbe, such as a route near the river or further inland. On 8 November 1841, the five states of Prussia, Mecklenburg-Schwerin, Denmark, Lübeck and Hamburg signed a treaty for the construction of a railway line between Berlin and Hamburg. The Mecklenburg side under Grand Duke Frederick Francis II succeeded in achieving a route that was as close as possible to the court in Mecklenburg Schwerin.

A few months before, representatives of the town of Grabow in Berlin had called for the railway to be connected to the town. In March 1841, it was agreed that the town of Grabow would provide the Berlin-Hamburg Railway Company (Berlin-Hamburger Eisenbahngesellschaft) with free land and materials for the construction. The company pledged in return to build at its own expense a station and a freight yard for transfers to and from traffic river on the Elde. First, it was proposed that the line from the town would run on a south-western tangent of the town with the station west of the harbour of Grabow, but later it was proposed that the line would run on the northeastern edge of the town. Both plans were favourable for the town as very little valuable land would have had to given to the railway and, in addition, the nearby town of Ludwigslust would be served at a distance. After a visit by Friedrich Neuhaus to Grabow, it was found that the final route would require the acquisition a number of valuable properties for railway construction and the town had to compensate the owners accordingly. In addition, the new route passed near central Ludwigslust and so greater competition was feared.

The line between Berlin and Boizenburg was opened on 15 October 1846 and it was the first railway line in Mecklenburg. The connection to Hamburg was completed on 15 December 1846. Stations were opened along with the line in Mecklenburg in Grabow, Ludwigslust, Hagenow, Brahlstorf and Boizenburg. In the first years of operation on the line, Grabow was on the customs border between Mecklenburg and Prussia. The establishment of the North German Confederation in 1867 created a customs union and the controls were abolished.

Navigation on the Elde was improved in the Grabow area in 1868. In response, a transhipment facility was established at the railway bridge in the southern part of the station precinct, where a crane transhipped goods between boats and rail wagons. However, demand remained low and the crane was dismantled in 1885. The area around the station was gradually developed in the second half of the 19th century. The Kießerdamm between the city and station was paved and an avenue of lime trees was built along it for pedestrians. A barrel factory was built at the station in 1858 and the district court and post office were built on Kießerdamm in the following decades. A residential area was established beyond the station in 1890.

There had been aspirations in the first decades after the construction of the line for another line running from Dömitz via Grabow to Parchim and Waren (Müritz); instead the neighbouring Ludwigslust station developed as a railway junction from 1880. As a result, Grabow Station was left behind compared with Ludwigslust.

After the Second World War, the transport patterns changed. The line between Hamburg and Berlin lost its importance due to the emergence of the Inner German border. Traffic between Rostock and Wismar towards Magdeburg and Leipzig, which used the Berlin–Hamburg Railway between Ludwiglust and Wittenberg, increased in importance.