The Grammy Award for Best Alternative Music Performance is an award presented by the Recording Academy to honor quality alternative music performances in any given year. The award was presented for the first time on February 5, 2023, at the 65th Annual Grammy Awards. It is a companion category to the Grammy Award for Best Alternative Music Album and the first new category in the alternative genre since the field's creation in 1991. The category sits in the Rock, Metal, & Alternative field.

The Academy stated that the award goes to "a track or single performance that recognizes the best recordings in an alternative performance by a solo artist, collaborating artists, established duo, or established group."

In 1991, and from 1994 to 1999, the award for Best Alternative Music Album was known as Best Alternative Music Performance. In this time, it was won by Sinéad O'Connor, U2, Green Day, Nirvana, Beck, Radiohead and Beastie Boys.

The category was one of five new categories announced in June 2022 alongside Best Americana Performance, Best Score Soundtrack for Video Games and Other Interactive Media, Best Spoken Word Poetry Album and Songwriter of the Year, Non-Classical.

^{^[I]} Each year is linked to the article about the Grammy Awards held that year.