The Great Lakes Intercollegiate Athletic Conference (GLIAC) is a college athletic conference affiliated with the National Collegiate Athletic Association (NCAA) at the Division II level.

The GLIAC was founded in June 1972. Its eleven member institutions are located in the Midwestern United States in the states of Michigan, Illinois, Indiana, and Wisconsin. There are three affiliate members who compete in the GLIAC for sports not sponsored by their home conference.

Sponsorship of football was dropped by the GLIAC after the 1989 season. Conference schools sponsoring football joined with members of the Heartland Football Conference to form the Midwest Intercollegiate Football Conference (MIFC), which began play in 1990. The MIFC merged with the GLIAC in July 1999, and the GLIAC resumed sponsorship of football that fall.

The GLIAC currently has 11 full members; all but two are public schools.

The GLIAC currently has three affiliate members, all but one are private schools:

The GLIAC had 13 former full members; all but one are private schools:

The GLIAC had nine former affiliate members, all were private schools. School names and nicknames reflect those in use in the final season each school was an affiliate:

Note: The GLIAC dropped football after the 1989 fall season (1989–90 school year) and resumed it since the 1999 fall season (1999–2000 school year).