The Greater Accra Region has the smallest area of Ghana's 16 administrative regions, occupying a total land surface of 3,245 square kilometres. This is 1.4 per cent of the total land area of Ghana. It is the most populated region, with a population of 5,455,692 in 2021, accounting for 17.7 per cent of Ghana's total population.

The Greater Accra region is the most urbanized region in the country, with 87.4% of its total population living in urban centres. The capital city of Greater Accra Region is Accra which is at the same time the capital city of Ghana.

In 1960, Greater Accra, then referred to as Accra Capital District, was geographically part of the Eastern Region. It was, however, administered separately by the Minister responsible for local government. With effect from 23 July 1982, Greater Accra was created by the Greater Accra Region Law (PNDCL 26) as a legally separate region.

The Greater Accra Region is bordered on the north by the Eastern Region, on the east by the Volta Region, on the south by the Gulf of Guinea, and on the west by the Central Region. It is smallest region of Ghana in total area, and is made up of 29 administrative areas.

The Ga people celebrate the Homowo festival, which literally means "hooting at hunger." This festival originated several centuries ago. It is celebrated in remembrance of a great famine that hit the Ga people in the sixteenth century. It is mainly a food festival which celebrates the passing of that terrible period in Ga history. It takes place in August every year and is celebrated by all the Ga clans.

The Adangbe people from Ada celebrate the Asafotu festival, which is also called 'Asafotufiam', an annual warrior's festival celebrated by Ada people from the last Thursday of July to the first weekend of August commemorates the victories of the warriors in battle and is a memorial for those who fell on the battlefield. To re-enact these historic events, the warriors dress in traditional battle dress and stage a mock battle. This is also a time for male rites of passage, when young men are introduced to warfare. The festival also coincides with the harvest cycle, when these special customs and ceremonies are performed. These include purification ceremonies. The celebration reaches its climax with a durbar of chiefs, a colourful procession of the Chiefs in palanquins with their retinue. They are accompanied by traditional military groups called 'Asafo Companies' amidst drumming, singing and dancing through the streets and on the durbar grounds. At the durbar, greetings are exchanged between the chiefs, libations are poured and declarations of allegiance are made.

The political administration of the region is through the local government system. Under this administration system, the region is divided into 29 MMDA's (made up of 2 Metropolitan, 23 Municipal and 4 Ordinary Assemblies). Each District, Municipal or Metropolitan Area and it's corresponding constituency, is administered by a Chief Executive and a Member of Parliament, representing the central government but deriving authority from an Assembly headed by a presiding member elected from among the members themselves. The MMDA's were increased from 3 to 5 in 1988; then from 5 to 6 in 2004; then from 6 to 10 in 2008; then from 10 to 16 in 2012; and recently from 16 to 29 in 2018. The number of constituencies increased/spread from 22 to 27 in 2004 making and 34 prior to the 2012 Ghanaian general election.The current list is as follows:

The center of population of the Greater Accra region is located in the Greater Accra Metropolitan Area which comprises the Accra Metropolitan, Tema Metropolitan, Adenta Municipal, La Nkwantanang Madina Municipal District, Ashaiman Municipal, Ledzokuku-Krowor Municipal, Ga East Municipal, Ga West Municipal, and Ga South Municipal districts