Manchester–Boston Regional Airport (IATA: MHT, ICAO: KMHT, FAA LID: MHT), informally referred to as Manchester Airport, is a public use airport 3 miles (5 km) south of the central business district of Manchester, New Hampshire, United States on the border of Hillsborough and Rockingham counties. It is owned by the city of Manchester, and is in the southern part of the city on the border with Londonderry, New Hampshire.

Opened in 1927, Manchester–Boston Regional Airport is by far the busiest airport in New Hampshire, with ten times the traffic of the next-busiest, Portsmouth. It is the only airport in the state with substantial commercial service. It is also New England's fifth-largest airport by passenger volume, behind Boston Logan in Massachusetts; Bradley International in Connecticut; T. F. Green in Rhode Island; and Portland International Jetport in Maine. It moved more than 1 million passengers in a year for the first time in 1997. After years of growth, it handled 4.33 million passengers in 2005, its peak year. Passenger tallies have declined since then, similarly with many regional airports; it handled 1.85 million passengers in 2018, and traffic fell sharply during the COVID-19 pandemic.

It is included in the Federal Aviation Administration (FAA) National Plan of Integrated Airport Systems for 2021–2025, in which it is categorized as a small hub primary commercial service facility. The facility was known as Manchester Airport until April 18, 2006, when it added "Boston Regional" to advertise its proximity to Boston, about 50 miles (80 km) to the south. Certified for Cat III B Instrument Landing operations, the airport has a reputation for never surrendering to bad weather. The airport has closed only once, when the national airspace was shut down for two days following the September 11 terrorist attacks, after which all American airports were required to close. It is home to the Aviation Museum of New Hampshire, built around an Art Deco control tower, and its terminal opened in 1938.

Manchester–Boston is New England's third-largest cargo airport behind Connecticut's Bradley International, which is a hub for UPS Airlines, and Logan in Boston. FedEx, UPS and Amazon all serve Manchester with cargo-specific jets, including the Airbus A300, Boeing 757, Boeing 767 and Boeing 737.

UPS uses Manchester to "feed" the rest of northern New England by contracting with Wiggins Airways, which flies smaller prop-driven planes to places like Portland, Augusta, Bangor, Presque Isle, Rutland, and other communities. To handle this "regional sort," UPS built a sorting facility where packages coming in from the company's Louisville hub are redistributed to trucks or to the Wiggins feeder aircraft.

FedEx previously used Manchester as a regional sorting station as well but now supports the northern New England destinations via direct flights from Memphis, Tennessee, to Portland and Burlington. A contract with the Postal Service fills the FedEx jets (coming from hubs in Memphis and Indianapolis) with mail in addition to the typical assortment of express and overnight packages. DHL previously operated a 727-200 on a Wilmington, Ohio-Allentown, Pennsylvania-Manchester-Wilmington routing, but that service has since ceased.

In November 2022, Amazon Air operated by Atlas Air began flying into Manchester utilizing Boeing 767 and Boeing 737 aircraft from Fort Worth Alliance Airport and Cincinnati/Northern Kentucky International Airport. Nightly flights arrive from Fort Worth Alliance Airport and Cincinnati/Northern Kentucky International Airport to Manchester and back to Cincinnati/Northern Kentucky International Airport and Fort Worth Alliance Airport in the early morning hours.

Manchester Boston Regional Airport covers an area of 1,500 acres (610 ha), which contains two asphalt runways: Runway 17/35 measuring 9,250 x 150 ft (2,819 x 46 m) and Runway 6/24 measuring 7,651 x 150 ft (2,332 x 46 m).