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HOXB7

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HOXB7

Homeobox protein Hox-B7 is a protein that in humans is encoded by the HOXB7 gene.

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.

HOXB7 has been shown to interact with PBX1 and CREB-binding protein.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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