Hamilton Southeastern High School (HSE or HSHS) is a public secondary school in Fishers, Indiana, United States. It is a part of the Hamilton Southeastern School District.

Location: Fishers, Indiana USA

Founded: 1964

During the 2003–2004 school year, the Hamilton Southeastern school district opened the Hamilton Southeastern High School Freshman Campus, which would house the district's high school freshmen until the 2006–2007 school year. In the fall of 2006, the HSE Freshman Campus became the second high school in the HSE school district, Fishers High School. In summer 2009, the cafeteria was expanded to accommodate more students.

A new cafeteria and hallway replaced much of the original HSE High School courtyard in the summer of 2010. The addition was part of a $1.5 million project to combat overcrowding and help ease foot traffic.

In 2012, freshmen were put into a Freshman Campus at the location of the old junior high until the senior wing addition, which opened for the 2015–2016 school year, was complete. The Freshman Campus then became Fall Creek Junior High School.

Beginning with the 2015–2016 school year, the newly built College and Career Academy was opened for students.

Hamilton Southeastern High School became a National Blue Ribbon School for 2004–2005, being in the top 4% of schools nationwide.