Hank Green was born in Indianapolis, Indiana, marking the beginning of a life characterized by intellectual curiosity and a passion for learning. His early years laid the foundation for his later pursuits in science, education, and creative endeavors. He is the younger brother of author John Green.

Together with his brother John, Hank launched the Vlogbrothers YouTube channel, initially as a year-long video correspondence project. This endeavor evolved into a dynamic platform for discussing a wide range of topics, from science and history to mental health and current events. The channel gained a massive following and fostered a passionate community known as 'Nerdfighters', united by their shared enthusiasm for knowledge and making the world a better place. Vlogbrothers videos significantly shaped the landscape of online education and communication.

Recognizing the needs of the growing online creator community, Hank co-founded DFTBA Records ('Don't Forget to Be Awesome') with Alan Lastufka. This e-commerce platform provided a space for creators to sell merchandise directly to their fans, bypassing traditional retail channels and fostering a direct connection with their audience. DFTBA Records became a cornerstone of the creator economy.

Hank launched SciShow, a YouTube channel dedicated to making science accessible and engaging for a broad audience. The channel's concise, informative videos covered a diverse range of scientific topics, from biology and chemistry to physics and astronomy. SciShow quickly gained popularity, becoming a leading source of online science education and helping to demystify complex concepts for viewers of all ages.

Hank founded Complexly, a production company that creates educational YouTube channels. This venture formalized and scaled Hank's commitment to online education, creating a platform for the production of multiple informative channels with high production quality. This umbrella of channels includes SciShow, Crash Course, and several others.

Hank and John Green teamed up to co-create Crash Course, an educational YouTube series covering a wide range of subjects, including World History, Literature, Biology, and Chemistry. Their engaging teaching style, coupled with high-quality animation and production values, made Crash Course a valuable resource for students and lifelong learners alike. The series has been widely adopted in classrooms and homes around the world.

Hank Green expanded his creative horizons with the publication of his debut novel, "An Absolutely Remarkable Thing". The science fiction novel, which explores themes of online fame, social media, and human connection, was a commercial and critical success, further solidifying Hank's status as a multi-talented creator. It was followed by a sequel, "A Beautifully Foolish Endeavor".

Hank Green publicly announced his diagnosis of Hodgkin's Lymphoma. He used his platform to document his treatment process and educate his audience about cancer, providing transparency and fostering a sense of community support. His willingness to share his personal health journey has been praised for its honesty and vulnerability.