Hank and his brother John Green begin Brotherhood 2.0, a year-long video blogging project where they cease all text-based communication and communicate solely through video blogs. This project marks the beginning of their YouTube career.

The Vlogbrothers channel grows rapidly, becoming a hub for discussions on a wide range of topics, including science, literature, pop culture, and mental health. The channel fosters a strong online community known as Nerdfighters.

Hank launches SciShow, a YouTube channel dedicated to explaining scientific concepts in an accessible and engaging way. SciShow quickly gains popularity, becoming one of the leading science education channels on YouTube.

Hank and his team expand their YouTube presence by launching several other channels, including SciShow Space, SciShow Psych, Crash Course Kids, Animal Wonders Montana, and Eons. Each channel focuses on a specific subject area, further broadening their educational reach.

Hank continues to produce content for various YouTube channels, collaborating with a team of writers, researchers, and editors to create high-quality educational videos.