Harpers Ferry is a historic town in Jefferson County, West Virginia, United States. The population was 269 at the 2020 United States census. Situated at the confluence of the Potomac and Shenandoah Rivers in the lower Shenandoah Valley, where Maryland, Virginia, and West Virginia meet, it is the easternmost town in West Virginia as well as its lowest point above sea level.

Originally named Harper's Ferry after an 18th-century ferry owner, the town lost its apostrophe in 1891 in an update by the United States Board on Geographic Names. It gained fame in 1859 when abolitionist John Brown led a raid on the Harpers Ferry Armory in a doomed effort to start a slave rebellion in Virginia and across the South. During the American Civil War, the town became the northernmost point of Confederate-controlled territory, and changed hands several times due to its strategic importance.

An antebellum manufacturing and transportation hub, Harpers Ferry has long since reoriented its economy around tourism after being largely destroyed during the Civil War. Harpers Ferry is home to John Brown's Fort (West Virginia's most visited tourist site), the headquarters of the Appalachian Trail, whose midpoint is nearby, the former campus of Storer College (a historically black college established during Reconstruction), and one of four national training centers of the National Park Service.

Much of the lower town, which was in ruins by the end of the Civil War and ravaged by subsequent floods, has been rebuilt and preserved by the National Park Service.

In 1733, squatter Peter Stephens settled on land near the confluence of the Potomac and Shenandoah Rivers and established a ferry across the Potomac from Virginia (now West Virginia) to Maryland.

Robert Harper, from whom the town takes its name, was born in 1718 in Oxford Township, Pennsylvania, now part of Philadelphia. Since he was a builder, Harper was asked by a group of Quakers in 1747 to build a meeting house in the Shenandoah Valley near the present site of Winchester, Virginia. Traveling through Maryland on his way to the Shenandoah Valley, Harper—who was also a millwright—realized the potential of the latent waterpower from the Shenandoah and Potomac Rivers at their confluence. He paid Stephens 30 guineas for his squatting rights to the ferry, since the land actually belonged to Lord Fairfax.

Harper then purchased 126 acres (0.51 km²) of land from Lord Fairfax in 1751. In 1761, the Virginia General Assembly granted him the right to establish and maintain a ferry across the Potomac. In 1763, the Virginia General Assembly established the town of "Shenandoah Falls at Mr. Harpers Ferry." Harper died in October 1782, and is buried in the Harper Cemetery.

On October 25, 1783, Thomas Jefferson visited Harpers Ferry as he was traveling to Philadelphia. Viewing "the passage of the Potomac through the Blue Ridge" from a rock that is now named for him as Jefferson's Rock, he called the site "perhaps one of the most stupendous scenes in nature" and stated, "This scene is worth a voyage across the Atlantic." The town was one of his favorite retreats, and tradition holds that much of his Notes on the State of Virginia was written there. Jefferson County, in which Harpers Ferry is located, was named for him on its creation in 1801.