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Head direction cell
Head direction (HD) cells are neurons found in a number of brain regions that increase their firing rates above baseline levels only when the animal's head points in a specific direction. They have been reported in rats, monkeys, mice, chinchillas and bats, but are thought to be common to all mammals, perhaps all vertebrates and perhaps even some invertebrates, and to underlie the "sense of direction". When the animal's head is facing in the cell's "preferred firing direction" these neurons fire at a steady rate (i.e., they do not show adaptation), but firing decreases back to baseline rates as the animal's head turns away from the preferred direction (usually about 45° away from this direction).
HD cells are found in many brain areas, including the cortical regions of postsubiculum (also known as the dorsal presubiculum), retrosplenial cortex, and entorhinal cortex, and subcortical regions including the thalamus (the anterior dorsal and the lateral dorsal thalamic nuclei), lateral mammillary nucleus, dorsal tegmental nucleus and striatum. It is thought that the cortical head direction cells process information about the environment, while the subcortical ones process information about angular head movements.
A striking characteristic of HD cells is that in most brain regions they maintain the same relative preferred firing directions, even if the animal is moved to a different room, or if landmarks are moved. This has suggested that the cells interact so as to maintain a unitary stable heading signal (see "Theoretical models"). Recently, however, a subpopulation of HD neurons has been found in the dysgranular part of retrosplenial cortex that can operate independently of the rest of the network, and which seems more responsive to environmental cues.
The system is related to the place cell system, located in the hippocampus, which is mostly orientation-invariant and location-specific, whereas HD cells are mostly orientation-specific and location-invariant. However, HD cells do not require a functional hippocampus to express their head direction specificity. They depend on the vestibular system, and the firing is independent of the position of the animal's body relative to its head.
Some HD cells exhibit anticipatory behaviour: the best match between HD activity and the animal's actual head direction has been found to be up to 95 ms in future. That is, activity of head direction cells predicts, 95 ms in advance, what the animal's head direction will be. This possibly reflects inputs from the motor system ("motor efference copy") preparing the network for an impending head turn.
HD cells continue to fire in an organized manner during sleep, as if animals were awake. However, instead of always pointing toward the same direction—the animals are asleep and thus immobile—the neuronal "compass needle" moves constantly. In particular, during rapid eye movement sleep, a brain state rich in dreaming activity in humans and whose electrical activity is virtually indistinguishable from the waking brain, this directional signal moves as if the animal is awake: that is, HD neurons are sequentially activated, and the individual neurons representing a common direction during wake are still active, or silent, at the same time.
The HD network makes use of inertial and other movement-related inputs, and thus continues to operate even in the absence of light. These inertial properties are dependent on the vestibular system, especially the semicircular canals of the inner ear, which signal rotations of the head. The HD system integrates the vestibular output to maintain a signal reflecting cumulative rotation. The integration is less than perfect, though, especially for slow head rotations. If an animal is placed on an isolated platform and slowly rotated in the dark, the alignment of the HD system usually shifts a little bit for each rotation. If an animal explores a dark environment with no directional cues, the HD alignment tends to drift slowly and randomly over time.
One of the most interesting aspects of head direction cells is that their firing is not fully determined by sensory features of the environment. When an animal comes into a novel environment for the first time, the alignment of the head direction system is arbitrary. Over the first few minutes of exploration, the animal learns to associate the landmarks in the environment with directions. When the animal comes back into the same environment at a later time, if the head direction system is misaligned, the learned associations serve to realign it.
Hub AI
Head direction cell AI simulator
(@Head direction cell_simulator)
Head direction cell
Head direction (HD) cells are neurons found in a number of brain regions that increase their firing rates above baseline levels only when the animal's head points in a specific direction. They have been reported in rats, monkeys, mice, chinchillas and bats, but are thought to be common to all mammals, perhaps all vertebrates and perhaps even some invertebrates, and to underlie the "sense of direction". When the animal's head is facing in the cell's "preferred firing direction" these neurons fire at a steady rate (i.e., they do not show adaptation), but firing decreases back to baseline rates as the animal's head turns away from the preferred direction (usually about 45° away from this direction).
HD cells are found in many brain areas, including the cortical regions of postsubiculum (also known as the dorsal presubiculum), retrosplenial cortex, and entorhinal cortex, and subcortical regions including the thalamus (the anterior dorsal and the lateral dorsal thalamic nuclei), lateral mammillary nucleus, dorsal tegmental nucleus and striatum. It is thought that the cortical head direction cells process information about the environment, while the subcortical ones process information about angular head movements.
A striking characteristic of HD cells is that in most brain regions they maintain the same relative preferred firing directions, even if the animal is moved to a different room, or if landmarks are moved. This has suggested that the cells interact so as to maintain a unitary stable heading signal (see "Theoretical models"). Recently, however, a subpopulation of HD neurons has been found in the dysgranular part of retrosplenial cortex that can operate independently of the rest of the network, and which seems more responsive to environmental cues.
The system is related to the place cell system, located in the hippocampus, which is mostly orientation-invariant and location-specific, whereas HD cells are mostly orientation-specific and location-invariant. However, HD cells do not require a functional hippocampus to express their head direction specificity. They depend on the vestibular system, and the firing is independent of the position of the animal's body relative to its head.
Some HD cells exhibit anticipatory behaviour: the best match between HD activity and the animal's actual head direction has been found to be up to 95 ms in future. That is, activity of head direction cells predicts, 95 ms in advance, what the animal's head direction will be. This possibly reflects inputs from the motor system ("motor efference copy") preparing the network for an impending head turn.
HD cells continue to fire in an organized manner during sleep, as if animals were awake. However, instead of always pointing toward the same direction—the animals are asleep and thus immobile—the neuronal "compass needle" moves constantly. In particular, during rapid eye movement sleep, a brain state rich in dreaming activity in humans and whose electrical activity is virtually indistinguishable from the waking brain, this directional signal moves as if the animal is awake: that is, HD neurons are sequentially activated, and the individual neurons representing a common direction during wake are still active, or silent, at the same time.
The HD network makes use of inertial and other movement-related inputs, and thus continues to operate even in the absence of light. These inertial properties are dependent on the vestibular system, especially the semicircular canals of the inner ear, which signal rotations of the head. The HD system integrates the vestibular output to maintain a signal reflecting cumulative rotation. The integration is less than perfect, though, especially for slow head rotations. If an animal is placed on an isolated platform and slowly rotated in the dark, the alignment of the HD system usually shifts a little bit for each rotation. If an animal explores a dark environment with no directional cues, the HD alignment tends to drift slowly and randomly over time.
One of the most interesting aspects of head direction cells is that their firing is not fully determined by sensory features of the environment. When an animal comes into a novel environment for the first time, the alignment of the head direction system is arbitrary. Over the first few minutes of exploration, the animal learns to associate the landmarks in the environment with directions. When the animal comes back into the same environment at a later time, if the head direction system is misaligned, the learned associations serve to realign it.