The Heliopolis Palace (Arabic: قصر رئاسة الجمهورية, Kasr Riasat Al Gomhouria, "Palace of the Presidency of the Republic" or قصر الاتحادية Kasr Al Ittihadia, "Federation Palace") is one of the five Egyptian presidential palaces and residences, the others being Abdeen Palace, Koubbeh Palace, Montaza Palace and Ras El Tin Palace, for the executive office of the President of Egypt. It is located in the suburb of Heliopolis, northeast of central Cairo and east of the Nile in Egypt. It was originally built as the grand Heliopolis Palace Hotel in 1910. Now it is for the use of the President of Egypt.

The palace was originally built as the luxurious Heliopolis Palace Hotel in the open desert from 1908 to 1910, while development of the new suburb began around it, by the Heliopolis Oases Company was ongoing. The hotel was designed by Ernest Jaspar as part of the larger Heliopolis project being done by Édouard Empain.

Billed as the most luxurious hotel in Africa and the Middle East, the Heliopolis Palace Hotel became, because of its grand architecture, an exclusive destination for guests including foreign royalty and international business tycoons. Guests included Milton S. Hershey and King Albert I and Queen Elisabeth of Belgium.

During the First World War, the Heliopolis Palace Hotel was transformed into a military hospital for Australian troops. The hospital employed students and nuns from the nearby Collège du Sacré-Cœur. The hospital was one of the largest and grandest in the campaign and was referred to in Australian press as "the Hospital in a palace." It made use of ambulances and had beds and tents lined up for miles along the road, making it able to treat thousands of Commonwealth troops at a time.

In 1958, the hotel was purchased by the Egyptian government and closed. It was used to house government offices. In January 1972, the building became the headquarters of the Federation of Arab Republics, the short-lived political union between Egypt, Libya and Syria, which gave it the current Arabic name of قصر الاتحادية Kasr Al Ittihadia ("Federation Palace").

In the 1980s, after extensive renovation and restoration efforts, the building became an Egyptian presidential palace and the headquarters of the administration of the new president, Hosni Mubarak. Today it is perhaps one of the more restricted presidential palaces regarding access. It is surrounded by simple gardens.

On December 4 2012, protesters opposed to Morsi’s 2012 constitutional declaration clashed with Morsi supporters (mainly Muslim Brotherhood members) the following day after getting attacked by them. The clashes led to at least 10 deaths to both sides, hundreds of injuries and the intervention of security forces, particularly the Republican Guard and Central Security Forces. Order was restored by the 6th of December.

The landmark hotel was designed by Belgian architect Ernest Jaspar. He introduced the local Heliopolis style of architecture, a synthesis of Persian, Moorish Revival, Islamic, and European Neoclassical architecture. It was built by the contracting firms Leon Rolin & Co. and Padova, Dentamaro & Ferro, the two largest civil contractors in Egypt then. Siemens & Schuepert of Berlin fitted the hotel's web of electric cables and installations. The utilities were to the most modern standards of their day. The hotel operations were under French administered management.