The High Evolutionary initiates the Evolutionary War, believing that only the 'fit' should survive. He attempts to accelerate the evolution of humanity, forcibly mutating individuals to test their adaptability. This leads to conflict with Earth's heroes, who oppose his methods.

The Celestials, ancient cosmic beings responsible for seeding life on various planets, disapprove of the High Evolutionary's meddling with evolution on a planetary scale. He faces their judgment and is often deemed to be unfit to continue his experiments.

Throughout his history, the High Evolutionary repeatedly attempts to realign cosmic forces to further his evolutionary goals. These efforts often involve complex scientific procedures and manipulation of cosmic energies, frequently resulting in unforeseen consequences.

At times, the Celestials or other cosmic forces have depowered him, reverting him to a normal human state, or near to it. This has led to reflection on his hubris, and sometimes to recommitting himself to a more moderate path.

The Evolutionary eventually regains his High Evolutionary powers, restarting his work. This marks another turning point. This cycle often repeats itself, showcasing the core conflict of his character.