His early partnership with Jonathan Drew demonstrates an early collegial relationship, which ultimately dissolved due to diverging priorities.

Given Wundagore Mountain is considered her birthplace and her connections to Chthon and chaos magic, there have been numerous encounters and storylines that involve Wanda Maximoff and the High Evolutionary. She is often manipulated in his plans, but has also acted as his enemy.

His relationship with the New Men and Knights of Wundagore is complex, bordering on servitude. While he views them as his creations and followers, they often exhibit signs of independent thought and loyalty.

The High Evolutionary's methods and goals often bring him into conflict with Earth's heroes, who oppose his forced evolution and ethical breaches. He is often portrayed as an antagonist, challenging their notions of freedom and autonomy.

Despite his antagonistic tendencies, the High Evolutionary occasionally forms alliances with heroes or villains when their goals align, albeit temporarily. These alliances are usually based on mutual benefit rather than genuine trust.