Herbert Edgar Wyndham is born in Manchester, England. From a young age, he demonstrates an exceptional intellect and a deep fascination with biology and evolution. He spends his youth poring over scientific texts, foreshadowing his future pursuits.

Wyndham pursues advanced studies in genetics, making significant breakthroughs in gene manipulation and accelerated evolution. He begins experimenting on animals, raising ethical concerns but pushing the boundaries of his scientific understanding. His initial experiments give him the conviction that evolution can be guided and accelerated.

Becoming increasingly isolated and disillusioned with conventional scientific institutions, Wyndham retreats to Mount Wundagore in Transia (Eastern Europe). There, he establishes a hidden citadel and begins to experiment on animals on a larger scale. His experiments create the New Men, anthropomorphic animal-human hybrids, who become his devoted servants and protectors. He renames himself the High Evolutionary.

Driven by his ambition to create a perfect society, the High Evolutionary uses advanced technology to create Counter-Earth, a duplicate of Earth situated on the opposite side of the sun. He populates it with evolved beings, aiming to guide their development towards a utopian ideal. However, this experiment is fraught with challenges and unforeseen consequences, reflecting the inherent flaws in his vision.

Throughout his career, the High Evolutionary frequently encounters Earth's superheroes, including the Avengers, Spider-Man, and the Fantastic Four. These interactions often stem from his experiments affecting Earth or his philosophical clashes with those who oppose his methods. These confrontations expose the ethical implications of his actions and the potential dangers of unchecked scientific ambition.

The High Evolutionary's scientific pursuits lead him to delve into cosmic mysteries, including the nature of the Celestials. He becomes entangled in their plans and the larger cosmic order, further expanding his understanding of evolution and its role in the universe. This involvement showcases his ambition to understand and influence not just earthly evolution, but the evolution of the cosmos itself.

The High Evolutionary continues his experiments, sometimes with more benevolent intentions, other times driven by a desperate desire to rectify past mistakes. He occasionally attempts to help humanity or specific individuals, showcasing a complex moral compass and a constant struggle between his scientific curiosity and his sense of responsibility. He is constantly re-evaluating his methods and philosophies, making him a dynamic and ever-evolving character.