An immune-mediated inflammatory disease (IMID) is any of a group of conditions or diseases that lack a definitive etiology, but which are characterized by common inflammatory pathways leading to inflammation, and which may result from, or be triggered by, a dysregulation of the normal immune response.^{[citation needed]}

IMIDs are caused by massive production of inflammatory cytokines. This is believed to be the result of an abnormal immune response.

IMIDs occur in genetically predisposed individuals, due to various environmental and host factors. Some reviews include psychosomatic factors.

Diseases considered as IMID include

Fatigue is a very commom symptom in IMIDs. Fatigue often changes markedly within days and from day to day.

IMIDs negatively effect organs and systems (including peripheral and central nervous systems) which may cause chronic fatigue, pain, skin manifestations, multiorgan dysfunction and sleep disturbance effects. Some IMIDs cause hyperalgesia (abnormal sensitivity to pain).

Meds, including biologics, help some IMID patients, although resistance may develop in time. Other IMID patients are unresponsive or intolerant to current meds.

Stem cell therapy and CAR-T therapy are being researched for IMID.