Irig (Serbian Cyrillic: Ириг, pronounced [ǐriɡ]; Hungarian: Ürög) is a town and municipality located in the Srem District of the autonomous province of Vojvodina, Serbia. The town has a population of 4,415, while Irig municipality has 10,866 inhabitants.

In Serbian, the town is known as Irig (Ириг), in Croatian as Irig, in Hungarian as Ireg or Ürög, in German as Irick, in Slovak as Irig, and in Rusyn as Ириґ.

Irig was first mentioned in the historical documents in 1225. In the 15th century, the masters of the town were Serbian despots Vuk Grgurević, Đorđe Branković, and Jovan Branković. During the 15th and 16th century, ten Orthodox monasteries were built in the surrounding of Irig (Two of those were located just near the town).

Between 1526 and 1699, the town was under Ottoman administration. During this time, it belonged to the Sanjak of Syrmia, and was the administrative seat of one of the seven nahijas in that sanjak. In 1665, the town had 2,000 houses, one mosque and two monasteries. In this time, Irig was mostly inhabited by Muslim population.

Since 1699, Irig was part of the Habsburg monarchy. In the 18th century, Irig was one of the most important market centers in Srem and most of its inhabitants were Serbs.

In 1795–1796, the population of the town was decimated by plague. Popular local story claims that the patient zero was Anđelija Kuzmanović. She attended her sister's funeral in the village of Krnješevci near Stara Pazova, and brought back with her the plague infested rug to Irig, thus inadvertently spreading the disease. Kuzmanović died from plague on 14 June 1795. Historically, the plague was brought to Zemun by the Ottoman merchants and soldiers in the spring of 1795. Frightened citizens escaped to their relatives on Fruška Gora, spreading the disease.

Austrian authorities didn't try to heal the diseased, except for providing some painkiller medications, as their main goal was to isolate Irig and the surrounding villages as denizens of Irig also fled into the mountain. Punishment for the breaking out of the military imposed quarantine was death. After four months the residents returned only to find the scorched town: out of 912 houses, Austrian authorities burned or demolished 402. From the total population of 4,813, 2,548 died of this disease. It took over 120 years for Irig to reach the 1795 population. In appreciation for establishing the strict border between two towns and preventing the spreading of the plague into the nearby Ruma, citizens of Ruma built the memorial on the location of this "border crossing", made from 800 bricks taken from the demolished houses in Irig, which still stands. Built in 1797 and named "Kipovi" ("Statues"), the monument is protected as the cultural monument.

In the late 19th and early 20th century, Irig was a district capital in the Syrmia County of the Kingdom of Croatia-Slavonia.